Five Prime Therapeutics: A Hidden Gem And A Derisked Speculation


  • Five Prime Therapeutics has its lead candidate, Bemarituzumab, in phase 3 trial targeting a specific form of gastric cancer.
  • Although there’s no phase 2 data, phase 1 has decent results.
  • Overall, at these low prices, we find the stock investible.
  • This idea was discussed in more depth with members of my private investing community, The Total Pharma Tracker. Start your free trial today »

Five Prime Therapeutics (NASDAQ:FPRX) is a small company that has been around for a number of years, and its 5-year chart looks pretty bad for those who invested it in the 2017s. Indeed, the stock is probably trading at all-time lows these days. However, its focus on targeting fibroblast growth factor receptors is a relatively novel approach against cancers, where FGFR is often implicated. The FGFR is a subfamily of Tyrosine Kinase Receptors (TKR), and is an approach that overcomes the problems with targeting TKRs alone:

Most of the TKR share intracellular signaling pathways; therefore, cancer cells tend to overcome the inhibition of one tyrosine kinase receptor by activating another. The future of TKI (Tyrosine Kinase Inhibitor) therapy will potentially come from multi-targeted TKIs that target different TKR simultaneously. It is crucial to understand the interaction of the FGF-FGFR axis with other known driver TKRs. Based on this, it is possible to develop therapeutic strategies targeting multiple connected TKRs at once. One correct step in this direction is the reassessment of multi target inhibitors considering the FGFR status of the tumor. Another opportunity arises from assessing the use of FGFR TKI on patients harboring FGFR alterations.

As we see here, targeting the FGF-FGFR axis allows targeting multiple TKRs at once, overcoming the ability of cancer cells in the cross-utilization of shared intracellular signalling of TKRs. This is interesting science; now we have to see how FPRX goes about developing Bemarituzumab, an antibody that inhibits fibroblast growth factor receptor 2b, or FGFR2b, and recruits tumor-killing NK cells into the tumor microenvironment.

According to the company, Bemarituzumab (bema) is:

  • an afucosylated, humanized IgG1 monoclonal antibody that selectively binds the b isoform of FGFR2
  • an inhibitor of ligand binding to FGFR2b and blocks FGF7/10 receptor activation
  • glycoengineered to enhance antibody-dependent cell- mediated cytotoxicity (ADCC)
  • isoform-specific, potentially improving tolerability


Bemarituzumab, targeting gastric and gastroesophageal junction cancer, has an ongoing Phase 3 trial. Phase 3 futility analysis is due on June 30, 2020.

The company has another ongoing phase 2 trial for Cabiralizumab + Opdivo in pancreatic cancer. Phase 2 trial data is due on December 15, 2020.


Previous trial data

Five Prime Therapeutics does not have a phase 2 trial supporting this phase 3. Instead, it has a phase 1 trial. Data from this trial was presented in a poster entitled “Phase 1 Results from the Phase 1/3 FIGHT Study Evaluating Bemarituzumab and mFOLFOX6 in Advanced Gastric/GEJ Cancer” at the ASCO Gastrointestinal Cancer Symposium in San Francisco.

The Phase 1 portion of the study did not select patients based on FGFR2B status; however, at the time of the ASCO publication, 2 patients with gastric/esophageal cancer were confirmed to be FGFR2 positive, with 1 achieving a PR and the other demonstrating a complete metabolic response. The data from the trial is as follows.


In 21 treated patients with late-line GC/GEJ and high FGFR2b overexpression:

  • ORR was 19.0% with 4 confirmed PRs.
  • Disease control rate at 6 weeks - 57.1%.
  • Median duration of response was 15.4 weeks.


  • Bemarituzumab was well-tolerated.
  • There were no dose-limiting toxicities.
  • Maximum tolerated dose was not reached during dose escalation.

Discussion: A 19% ORR in this heavily pre-treated patient population is very decent-looking data. The drug was also very safe, with MTD not having been reached, although phase 3 dosage was fixed at 15mg/kg every 2 weeks based on the half-life. The safety profile is good for combination therapy with chemo drugs; here, the 10% patients with FGFR2 overexpression can benefit from the drug, while the rest can benefit from chemo.

Phase 3 trial has OS as primary endpoint, and it will select only those patients who have the FGFR2B receptor overexpressed in their tumors. This will be a conclusive trial, and early data does promise a good outcome from it. The first patient has already been dosed in this 550-patient trial.


The company is well-funded, with a market cap of $326.3 million, a cash balance of $237 million as of the March quarter, and cash burn was -32.68 million last year.

Here’s a chart showing recent insider buy/sells:


And here’s a quick snapshot of fund ownership:


The company has license and collaboration agreements with Bristol-Myers Squibb Company (BMY), GlaxoSmithKline LLC (GSK), INBRX 110 LP, UCB Pharma S.A., and Zai Lab (Shanghai) Co., Ltd. (ZLAB); a collaboration agreement with Roche (OTCQX:RHHBY); and license agreements with Galaxy Biotech, LLC, BioWa, Inc. and Lonza Sales AG.


Gastric cancer (GC)/gastroesophageal junction (GEJ) cancer is the 3rd most common cause of cancer death globally. Current therapies include surgery, radiotherapy, chemotherapy, and targeted therapies like Herceptin, which only works if the corresponding receptor is present in the tumor - i.e., it is HER2-positive; this constitutes about 9-38% of patients. FGFR2 amplification/ FGFR2b overexpression is associated with difficult-to-treat disease. This is present in approximately 5-10% of patients with GC/GEJ. This is the target population of Bemarituzumab.

Another successful therapeutic target in a subgroup of patients with GEA includes single-agent anti-PD-1 therapy in later-line settings. Microsatellite instability (MSI-High) occurs in approximately 2–3% of GC, and pembrolizumab has recently received regulatory approval for previously treated patients with any MSI-High solid tumor, including GC [14]. Additionally PD-L1 expression, as defined by combined positivity score occurs in approximately 50% of GEA patients at the cut-off of combined positivity score ≥1. Recently, pembrolizumab monotherapy has demonstrated activity and gained conditionally approval for these patients in the third-line setting or higher.

There are a number of pan-FGFR inhibitors in various stages of trials. A list is available here, but from 2017.

Bemarituzumab has no competition in its specific target population. If successful, it should become the standard of care in this population. There are approximately 3000 patients in the US every year who will be eligible for this treatment. Assume an equal number in the EU, and much larger figures in Asia (where FPRX collaborates with Zai Labs), and we are looking at a drug that can make $1 billion in potential sales, assuming a price tag of $150,000 per patient per year.


That the drug didn’t see a phase 2 trial presents a distinct risk at this stage. However, decent data from the phase 1 trial is some consolation.

The company has enough cash - and strong collaboration partners - to see it through the trial. However, it will have to pay royalty fees. For the collaboration with Zai Labs, they have a peculiar arrangement where each party has to pay the other royalty fees in different territories. FPRX has another royalty fee arrangement with BioWa. With Bristol Myers-Squibb, it has a similar royalty agreement; however, the company says this might have expired. The same goes for another royalty agreement it has with GlaxoSmithKline.


FPRX is trading at 52-week lows. Given the data we presented, we think it is suitable for a small investment at this stage.

Thanks for reading. At the Total Pharma Tracker, we do more than follow biotech news. Using our IOMachine, our team of analysts work to be ahead of the curve.

That means that when the catalyst comes that will make or break a stock, we’ve positioned ourselves for success. And we share that positioning and all the analysis behind it with our members.

This article was written by

Avisol Capital Partners profile picture
Cautious, low key, disciplined investing in biopharma stocks
Avisol Capital Partners runs the Total Pharma Tracker Seeking Alpha Marketplace service. This is managed by Dr Asok Dutta, BVScAH and Dr Udaya Kumar Maiya, MD Oncologist. The service offers end-to-end research on both investing and trading ideas everyday, and includes a 150-stock watchlist and two 40-stock model portfolios that are continuously tracked.

Dr Dutta is a retired veterinary surgeon. He has over 40 years experience in the industry. Dr Maiya is a well-known oncologist who has 30 years in the medical field, including as Medical Director of various healthcare institutions. Both doctors are also avid private investors. They are assisted by a number of finance professionals in developing this service.

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Disclaimer - we are not investment advisors.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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