Revolution Medicines Publishes First IPO Filing

Jan. 20, 2020 6:54 PM ETRevolution Medicines, Inc. (RVMD)

Summary

  • Revolution Medicines has filed to raise $100 million in an IPO, although that is a typical placeholder figure.
  • The firm is advancing a pipeline of drug candidates target the RAS and mTOR cancer pathways.
  • RVMD has an enviable investment and collaboration relationship with pharma giant Sanofi.
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Quick Take

Revolution Medicines (NASDAQ:RVMD) has filed to raise $100 million in an IPO of its common stock, according to an S-1 registration statement.

The company is a clinical stage biopharma developing treatments for cancers with an emphasis on the RAS and mTOR signaling pathways.

RVMD has a significant partnership collaboration with investor Sanofi (SNY), and I await more information about management's proposed pricing and valuation expectations.

Company & Technology

Redwood City, California-based Revolution was founded to advance a pipeline of drug candidates for the treatment of a variety of cancers, including solid tumors.

Management is headed by President and CEO Mark Goldsmith, M.D., Ph.D, who has been with the firm since November 2014 and was previously President and CEO of Constellation Pharmaceuticals.

Below is a brief overview video of SHP2 inhibitor aspects:

Source: ecancer

The firm's lead candidate, RMC-4630, is currently in Phase 1/2 trials and is an SHP2 inhibitor that seeks to overcome resistance to current RTKi cancer treatment regimens.

Below is the current status of the company's drug development pipeline:

Source: S-1

Investors in the firm have invested at least $305 million and include Third Rock Ventures, The Column Group, and Sanofi Research Invest (SNY).

Market & Competition

According to a 2019 market research report by ResearchandMarkets, the global market for solid tumor cancer treatment was more than $121 billion in 2018 and is expected to reach $424 billion by 2027. This represents a forecast very strong CAGR (Compound Annual Growth Rate) of 15.0% from 2019 to 2027.

Key elements driving this expected growth are an increase in breast cancer incidence as well as lung cancer due to rising air pollution and the number of cigarette smokers worldwide. North America accounts for 33.6% of demand for solid tumor cancer treatments followed by Europe at 30.2% and the Asia Pacific region

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This article was written by

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