Corcept Therapeutics: A Status Check


  • Today, we put the spotlight on Corcept Therapeutics for the first time in more than a year.
  • The company's Korlym is delivering steady sales and earning growth, the company has a solid balance sheet, and Corcept Therapeutics is also advancing its pipeline.
  • An investment analysis follows in the paragraphs below.
  • Looking for a portfolio of ideas like this one? Members of The Biotech Forum get exclusive access to our model portfolio. Learn More »

Molecule of cortisol hormone and adrenal gland

Dr_Microbe/iStock via Getty Images

Human beings are born with different capacities. If they are free, they are not equal. And if they are equal, they are not free. ― Aleksandr Solzhenitsyn

It has been just over a year since we last looked in on Corcept Therapeutics (NASDAQ:CORT). And given there has been no articles on Seeking Alpha around mid-cap biopharma name here in 2022, it seems to be a good time to revisit this name and update any potential investment thesis around Corcept Therapeutics. An analysis follows below.

CORT Stock Chart

Seeking Alpha

Company Overview:

Corcept Therapeutics is based in Menlo Park, California. The company has one approved product on the market and is advancing several others in its pipeline. These candidates were created by focusing on the development of drugs that treat severe metabolic, oncologic, and psychiatric disorders by modulating the effects of the hormone cortisol. The stock currently trades around $25.50 a share and sports an approximate market capitalization of $2.75 billion.

Corcept Therapeutics - Cortisol

Company Website

The company's one approved drug is called Korlym (mifepristone). This compound provides for the regulation of cortisol levels and was approved a decade ago. Cortisol is a steroid hormone that plays a significant role in the way the body reacts to stressful conditions in many different areas of the body. Korlym is a once-daily oral medication approved for the treatment of hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery or are not candidates for surgery.

Corcept Therapeutics - Korylm

May Company Presentation

Second Quarter Results & Recent Developments:

The company posted second quarter results on August 3rd. Corcept delivered GAAP earnings per share of 27 cents as revenues rose 13% on a year-over-year basis to $103.4 million.

Korlym a few drawbacks. It can produce hypokalemia (low potassium) in patients. Also in women the compound has been known to cause endometrial thickening, vaginal bleeding, and in some cases pregnancy termination. The company is currently developing Relacorilant as an improved version of Korlym without these drawbacks.

Enrollment continues in a Phase 3 'GRACE' trial of relacorilant as a treatment for patients with all etiologies of Cushing's syndrome. If successful, the company plans to be able to file an NDA by the second half of 2023 with the FDA. Enrollment also continues for Phase 3 'GRADIENT' study of relacorilant as a treatment for patients with Cushing's syndrome caused by adrenal adenomas.

Corcept Therapeutics Pipeline

May Company Presentation

Relacorilant is also being developed as part of various combination therapies for different forms of cancer. The company recently initiated a pivotal 360-patient Phase 3 trial of relacorilant plus nab-paclitaxel, better known as Abraxane, in patients with recurrent, platinum-resistant ovarian cancer. Two much earlier stage trials as part of a different combination therapies are currently ongoing.

Corcept Therapeutics - Platinum Resistant Cancer

May Company Presentation

In addition, the company is also developing a compound called miricorilant, a cortisol modulator, for metabolic disorders. Two trials, GRATITUDE and GRATITUDE II, are currently ongoing. They are evaluating miricorilant to reverse recent and long-standing antipsychotic-induced weight gain. Data from both trials should be out before the close of this year. An earlier stage effort is targeting non-alcoholic steatohepatitis or NASH.

Corcept Therapeutics - Metabolic Illness

May Company Presentation

Finally, the company is advancing a compound called dazucorilant that is targeting ALS, commonly known as Lou Gehrig's Disease. Dazucorilant is a selective cortisol modulator that crosses the blood-brain barrier that has shown promise in animal studies. A near 200-person Phase 2 study 'DAZALS' should kick off soon at sites in Europe and the United States.

Analyst Commentary & Balance Sheet:

Approximately one out of every five shares is current held short. Several insiders have sold shares in 2022. Total disposition of equity is just under $12 million in aggregate so far this year. The last insider purchase in this equity was late in 2020. After posting net income of $27.4 million, the company had cash and marketable securities of just north of $380 million on its balance sheet.

Since late June, four analyst firms including Jefferies and H.C. Wainwright have reiterated Buy ratings on CORT. Price targets proffered range from $33 to $45 a share. Here is the commentary from Canaccord Genuity's analyst who maintained his buy rating on the equity and bumped up his price target four bucks a share to $34 on June 27th.

Korlym is a "highly effective drug," inducing clinical improvement in patients with Cushing's syndrome. Corcept is also developing relacorilant for advanced ovarian cancer, a tumor type in which cortisol pathway activity is elevated, says the analyst. The analyst believes the company's pipeline offers upside potential in oncology and metabolic disorders and says the Korlym base business "provides a valuation floor."

Truist Financial seems the lone dissenter in the shares at the moment. They downgraded Corcept Therapeutics to a Hold with a $30 price target on August 1st.


The current analyst consensus calls for the company to make 89 cents a share in profit in FY2022 as revenues rise some 14% to $416 million. Earnings are projected to grow to a $1.03 a share in FY2023 on sales growth of 11% to 12%.

There is a lot to like about Corcept the company. It has a rock-solid balance sheet and is nicely profitable. Corcept is delivering steady and consistent growth. Relacorilant has promise as well. The question is what valuation do these assets and sales/earnings growth in the low teens merit in an environment with rising interest rates? At some 30 times this year's projected earnings, CORT seems more than fairly valued at current trading levels. If the stock pulled back in the high teens, I would probably be motivated to take a small position in the stock at that time.

Politics: the art of using euphemisms, lies, emotionalism and fear-mongering to dupe average people into accepting--or even demanding--their own enslavement. ― Larken Rose

Live Chat on The Biotech Forum has been dominated by discussion of lucrative buy-write or covered call opportunities on selected biotech stocks over the past several months. To see what I and the other season biotech investors are targeting as trading ideas real-time, just join our community at The Biotech Forum by clicking HERE.

This article was written by

Bret Jensen profile picture
Finding tomorrow's big winners in the lucrative biotech sector

Finding tomorrow's big winners in the lucrative biotech sector, The Biotech Forum focuses on proprietary, breaking research on promising biotech and biopharma stocks with significant potential for outsized alpha. It is the fourth most subscribed to investment service offered through the Marketplace on Our service offers a model-20 stock portfolio as well as the most active Live Chat on the Marketplace. This is where scores of seasoned biotech investors trade news and investment ideas back and forth throughout the trading day.

• • •

Specializing in profiling high beta sectors, Bret Jensen founded and also manages The Biotech Forum, The Insiders Forum, and the Busted IPO Forum model portfolios. Finding “gems” in the biotech and small-cap stock sectors, these highly volatile spaces proven hugely successful have empowered Bret Jensen's own investing portfolio.

• • •

Learn more about Bret Jensen's Marketplace Offerings:

The Insiders Forum | The Biotech Forum | Busted IPO Forum

Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Recommended For You

Comments (1)

To ensure this doesn’t happen in the future, please enable Javascript and cookies in your browser.
Is this happening to you frequently? Please report it on our feedback forum.
If you have an ad-blocker enabled you may be blocked from proceeding. Please disable your ad-blocker and refresh.