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SHIRE PLC - Diabetic Foot Ulcers (DFUs) PR

|Includes: AZN, LLY, PFE, SHPG, Shire PLC (SHPG)

SAN DIEGO, Nov. 14, 2013 /PRNewswire/ -- Diabetic Foot Ulcers (DFUs) are one of the most common, yet treatable, complications in people with diabetes. As part of World Diabetes Day, Shire is today urging diabetes patients to have their feet checked and visit to better understand the complications associated with diabetes.

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"On World Diabetes Day, we want to emphasize the importance of regular check-ups and urge patients to visit their doctor or local wound care center to have their feet checked. Symptoms of diabetes complications, such as DFUs, are frequently overlooked and can have devastating consequences," saysAdi Mohanty, Interim Head of Shire's Regenerative Medicine business unit.

Of the more than 26 million people in the US with diabetes, about half will develop peripheral neuropathy, a loss of feeling in the lower extremities.[i] This nerve damage means an open sore or injury on the foot may go unnoticed until it becomes infected, which can eventually lead to the need for a partial or full amputation of the foot or lower leg. Diabetes is responsible for more than half of all lower limb amputations performed in the U.S. Each year there are about 88,000 non-injury amputations, and 50 - 75% of them are due to diabetes. About 85% of amputations start with foot ulcers, which develop in about 12% of people with diabetes.[ii]

"Wound Care Centers are great places to have your feet checked," saysHan Pham Hulen, MD and Medical Director, Medical City Dallas Center for Wound Healing and Hyperbaric Medicine. "Staff at these facilities are extremely experienced in identifying and treating diabetic foot ulcers, which often go unnoticed. They specialize in early diagnosis, advanced wound care therapy, and educating patients on how to prevent or treat DFUs, so we encourage diabetics to visit their local centers."

Earlier this year, Shire teamed up with celebrity chef,Charles Mattockson his national tour, The Diabetic You, promoting diabetes awareness and education, a theme of World Diabetes Day since 2009. The mobile tour offers education, as well as healthy eating tips in an effort to increase people's awareness of diabetes, and help them manage the condition.

Shire also recently launched an educational resource,, which is designed to educate patients with diabetes and their caregivers on identifying, treating and preventing, diabetic foot ulcers. The website is the foundation of Shire's nationwide HealTogether program which is dedicated to promoting proper foot care for people with diabetes, educating individuals about DFUs, and encouraging those with non-healing DFUs to talk to their doctors about seeing a wound care specialist. To access more information on diabetic foot ulcers please visit

About Diabetic Foot Ulcers (DFUs)

Diabetic foot ulcers are wounds that can develop on the feet of people with diabetes. They are often difficult to heal and may become chronic in nature.

There are several reasons that wounds may not heal, but one major reason may be that over time high blood sugar levels can injure blood vessels, which may result in decreased blood flow to the wound.[iii]

DFUs are a common complication in patients with diabetes. Among people with diabetes, up to 25% experience a DFU in their lifetime[iv] and the annual incidence is approximately 3.4%[v],[vi]


Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal, Internal Medicine and Regenerative Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas.


Statements included in this announcement that are not historical facts are forward-looking statements. Forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, Shire's results could be materially adversely affected. The risks and uncertainties include, but are not limited to, that:

-- Shire's products may not be a commercial success;-- revenues from ADDERALL XR are subject to generic erosion;-- the failure to obtain and maintain reimbursement, or an adequate levelof reimbursement, by third-party payors in a timely manner for Shire'sproducts may impact future revenues and earnings;-- Shire relies on a single source for manufacture of certain of itsproducts and a disruption to the supply chain for those products mayresult in Shire being unable to continue marketing or developing aproduct or may result in Shire being unable to do so on a commerciallyviable basis;-- Shire uses third party manufacturers to manufacture many of its productsand is reliant upon third party contractors for certain goods andservices, and any inability of these third party manufacturers tomanufacture products, or any failure of these third party contractors toprovide these goods and services, in each case in accordance with itsrespective contractual obligations, could adversely affect Shire'sability to manage its manufacturing processes or to operate itsbusiness;-- the development, approval and manufacturing of Shire's products issubject to extensive oversight by various regulatory agencies andregulatory approvals or interventions associated with changes tomanufacturing sites, ingredients or manufacturing processes could leadto significant delays, increase in operating costs, lost product sales,an interruption of research activities or the delay of new productlaunches;-- the actions of certain customers could affect Shire 's ability to sellor market products profitably and fluctuations in buying or distributionpatterns by such customers could adversely impact Shire's revenues,financial conditions or results of operations;-- investigations or enforcement action by regulatory authorities or lawenforcement agencies relating to Shire's activities in the highlyregulated markets in which it operates may result in the distraction ofsenior management, significant legal costs and the payment ofsubstantial compensation or fines;-- adverse outcomes in legal matters and other disputes, including Shire'sability to obtain, maintain, enforce and defend patents and otherintellectual property rights required for its business, could have amaterial adverse effect on Shire's revenues, financial condition orresults of operations;

and other risks and uncertainties detailed from time to time in Shire's filings with the U.S. Securities and Exchange Commission, including its most recent Annual Report on Form 10-K.

[i] American Diabetes Association, Accessed November 13, 2013.

[ii] New York Times, Health Guide, Accessed November 8, 2013

[iii] American Diabetes Association. Living with diabetes: other specialists. Accessed November 8, 2013.

[iv] Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. J Amer Med Assoc. 2005;293:217-228.

[v] Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJ. Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care. 2003;26:1435-1438.

[vi] American Diabetes Association. Living with diabetes: foot care. Accessed January 27, 2013.

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