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Alpine Immune Sciences: What The Q1 2018 Earnings Foretell?

|About: Alpine Immune Sciences, Inc. (ALPN), Includes: GILD, JAZZ, KITE
Summary

Alpine is a stellar young grower hitting its next growth inflection, as reflective by various corporate developments.

Company recently procured a strong earnings report with significant catalysts to boost the share price.

Superb preclinical data for the lead molecule (ALPN-202) presented at the 2018 American Association for Cancer Research Annual Meeting.

ALPN-101 and -202 is projected to hit the clinics in late 2018 and early 2019, respectively.

Alpine is an enticing acquisition prospect in this highly conducive merger and acquisition environment.

Without a saving faith in the future, no one would ever invest at all. To be an investor, you must be a believer in a better tomorrow. - Benjamin Graham

In a Seeking Alpha interview back on Sep. 23, 2017, the ingenious market strategist (Robyn Conti) inquired, “What’s one idea you feel strongly about in the biotech space, and what’s the story?” Without hesitation, we responded Alpine Immune Sciences (NASDAQ:ALPN) - a young bioscience having an extremely favorable chance of either getting acquired or becoming the next 150-bagger, Jazz Pharmaceuticals (NASDAQ:JAZZ) in the long run. Accordingly, Alpine is leveraging on its extremely powerful therapeutic innovation platform to brew ALPN-101 and -202 (molecules that have strong multi-blockbuster prospects). Despite that the wait for Alpine’s shares to move has been over half-a-year, the stock is now trading northbound. In this research, we’ll analyze the latest earnings report and what Alpine has in store for shareholders.

Figure 1: Alpine stock chart (Source: StockCharts).

About The Company

As usual, we’ll go over the corporate background for readers new to Alpine. We stated in the prior research,

Headquartered in Seattle WA, Alpine leverages on the power of the naturally-occurring immune system proteins to develop a technology coined “direct evolution.” The aforesaid tool is used to engineer enzymes native to the immune synapses, thereby innovating them for the treatment of cancers, autoimmune and inflammatory diseases (as shown in figure 2). It is interesting to note that direct evolution is highly versatile. Accordingly, the ingenious science enabled vIgD to concurrently turn on an immune molecule while inhibiting another. Ultimately, this makes vIgD a superbly flexible designing tool with the vast applications for many autoimmune and inflammatory disorders. In addition, TIP delivers the second knockout punch for Alpine shareholders, as it enhances the functioning of next-generation cancer therapeutic, chimeric antigen receptor and T cell receptor (CAR-TCR). Consequently, the leveraging-power allowed Alpine to secure the $535M dealback in 2015 with Kite Pharma (NASDAQ:KITE), a firm under our coverage that was acquired by Gilead Sciences (NASDAQ:GILD). Of note, the company is currently brewing two stellar molecules. The most advanced is ALPN-101(the first-in-class dual ICOS/CD28 antagonist) that has a planned initial new drug application (“IND”) in Q4 2018. The other drug (ALPN-202) is a dual PD-L1 and CTLA-4 blocker as well as a CD28 agonist (projected to be available in the clinic in 2019).

Figure 2: Therapeutic pipeline (Source: Alpine).

Final Remarks

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Disclosure: I am/we are long ALPN.

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