The TTM P/E for the Nasdaq crossed above 110 in February 2000, about a month before the top. The biotech index currently sports an adjusted p/e of around 110.
Jonathan Verenger, "Are Biotechs In A Bubble?" July 7, 2015.
Additional disclosure: Quotations are not indications of my opinion one way or another. They are just little things I pick up in the course of my editorial workday.