Please Note: Blog posts are not selected, edited or screened by Seeking Alpha editors.

Initiating Coverage On Accurexa (ACXA) $2.50.

|Includes: Medisun Precision Medicine Ltd. (MPME)

==================================================

Stem Cell Stock Review, Monday, 03/23/2015.

Los Angeles, CA 58 …69F Fair.

Chicago, IL 31…45F Partly Cloudy.

Delray Beach, FL 72…87 Partly Cloudy.

Port Jefferson, NY 24…34F Fair. (198)

To contact us send an email to: biotechstockreview@gmail.com

==================================================

1. Initiating Coverage on Accurexa (ACXA) $2.50.

2. Disclaimer.

==================================================

1. Initiating Coverage on Accurexa (ACXA) $2.50.

Accurexa Inc.

201 Spear Street

Suite 1100

San Francisco, CA 94105

Phone: 415-494-7850

Website: www.accurexa.com

"Drug delivery remains a major issue in brain tumor treatment…treatment failures can be expected on the basis of inadequate drug delivery alone, regardless of the effectiveness of the drug." Mir J. Ali MD, Northwestern University Medical School.

"Failures expected, regardless of the effectiveness of the drug?"

Them's some fighting words to the billion dollar brain cancer drug industry. But it is what it is and we've found the company that believes it has come up with a bigger and better trap (a device called BranchPoint) to deliver drugs to the brain - that could become the new standard for brain drug delivery - and make tens, if not hundreds of millions along the way if they are successful at doing it.

This very exciting (some might say butt-kicking) medical device, which was developed at the UC San Francisco and initially funded with a $1.8 million grant from California's Institute for Regenerative Medicine (CIRM) and "rolled" into a publicly traded shell last summer - enabling investors (should they choose) to participate.

Photo of BranchPoint: www.accurexa.com/technology.html

CIRM, if you're unfamiliar is the nation's model of technology funding for "society's benefit" created by the kindness of the heavily taxed citizens of California, when they voted Proposition 71 though. The passage allocated $3 billion to establish the CIRM and created a biotech (stem cell) research hub rivaling Silicon Valley. So a shout out to California's taxpayers.

This is an enticing, yet simple story to follow.

Device Background:

Failures expected: Way back in 2006, Dr Mir from Northwestern University Medical School took task to the recurring question "Is treatment failure of the brain's malignant tumors due to inadequate delivery or ineffective drugs?" Without going into details (see link to follow), he concluded that treatment failures are likely due to high interstitial fluid pressure. Because the infusion rates being used in the treatment of human brain tumors are low and the tumors are larger, treatment failures can be expected on the basis of inadequate drug delivery alone, regardless of the effectiveness of the drug.

What this means to the stem cell industry, is if the delivery system fails - we risk total clinical trial failures - even if the biological reaction was valid. We cannot (should not) risk a $100 million clinical trail process to a $2.00 syringe. That's clearly unacceptable. End of that story. And beginning of Accurexa story.

Dr. Mir's study:

www.pubfacts.com/detail/16533759/Isolati...

Failures averted: Fast forward to 2010 when Dr. Daniel Lim, a genius neurosurgeon and assistant professor at the University of California, San Francisco, who regularly uses a surgical device (a regular syringe with a steel needle developed in 1986) to deliver potentially life-changing treatments into patients' brains comes up with self described "crazy sounding idea" to improve the delivery of therapeutics (aka drugs) to the brain. It was after a using the standard device during a study of an experimental stem cell therapy at UCSF, Lim thought "...there must be a better way."

In a San Francisco Business Journal article Lim stated, "...every time Parkinson's disease patients, for example, need cells transplanted into the brain, some must endure upwards of 10 injections because implanted cells don't spread through brain tissue. Every penetration, risks setting off bleeding in the brain."

"Every time you put a needle into the brain, you run the risk of a hemorrhage and raise the risk of unwanted effects," says Ian Duncan, a neuroscientist at the University of Wisconsin­-Madison.

"As experimental stem cell treatments progress, it only makes sense to use a tool built to deliver those cells rather than one designed nearly three decades ago. This could cut down on clinical trial failures at a critical time for scientists developing those treatments."

So what does he do?

Lim sketched his new device and turned it over to a group of UC Berkeley engineering students, who created a prototype. Then he won a $1.8 million grant in 2010 from the California Institute for Regenerative Medicine, the state's stem cell research funding organization, to push it through preclinical testing. Remember this "funding" point, because while our upcoming report will talk a lot about the deliver of stem cells to the brain (after-all that's where the until funding came from) we believe that the BranchPoint needle platform will be developed to deliver much more than just stem cells.

Not unlike current delivery methods, Lim's instrument sits in a massive frame that is mounted on the head of a patient. A hole is drilled in the skull and doctors deliver cells or direct brain stimulation or other treatments to the brain.

But instead of drilling multiple holes in the skull, the Accurexa device allows doctors to use a single entry point. They then can insert the hollowed, drug-bearing "plunger" - the diameter of hair - multiple times to multiple locations delivering treatments to as much as six locations in an hour.

Unlike other needles used for cell therapies, Lim's device contains no ferromagnetic metals and so is compatible with MRI. The imaging enables researchers to monitor patients for signs of hemorrhaging and to combine cell therapy with other techniques, such as depositing electrodes for deep brain stimulation, an experimental therapy for Parkinson's disease.

In fact, that's part of the beauty of the device: It could deliver cells, an electrode and gene therapy in a single session.

"As a clinician, I tried to think it all the way through," Lim said. Ultimately, he said, the device could convince some drug developers to look anew at experimental treatments that had been developed as oral drugs but which may be hundreds of times more effective when delivered directly into the brain.

"Up till now," Ivar Mendez, a neurosurgeon at Dalhousie University in Halifax, Canada says, "The way the injection has been done was with very primitive systems."

Company Background:

In our view, the Accurexa was essentially born, when they announced that they entered into their exclusive letter of intent (LOI) with the University of California, SF in regards to the exclusive global licensing of the BranchPoint device intended for the delivery of stem cells into the human brain. The LOI in July of 2014 became an actual license agreement in September of 2015.

Prior to the UCSF agreement, Accurexa's primary mission was to usher through technology licensed from the University of Arkansas for Medical Sciences, focused on detecting metastatic cancer cells. That technology could take another three or four years to win FDA approval, whereas Accurexa plans the filing of its 510(k) marketing clearance application this summer or fall, before its "small business status" qualification status, which was granted by the FDA last week expires in September of this year.

The agreement came after Lim was introduced to George Yu, the president and CEO of Accurexa. George whose background includes stints at Bain & Company, with small-cap hedge and venture capital funds and in investment banking at Lehman Brothers. Mr. Yu holds a Medical Doctor Degree from the University of Tuebingen, Germany, and a Master in Business Administration in Finance and Economics from Columbia Business School.

An equally impressive resume is that of board member, Anchie Kuo. Dr. Kuo was a Managing Partner and co-Founder of Genaissance Capital Group, a top quartile healthcare focused hedge fund. He was also Managing Director of BankAmerica Ventures (Scale Ventures Partners), a venture group that managed approximately $1.2 billion of assets. He is a physician, venture capitalist and entrepreneur with over 25 years of experience in the healthcare industry, serving on the board of over 15 companies.

In mid-January, Lim Development was awarded a two-year contract with the company for $200,000 which may be converted into stock at $0.20 a share or one million shares. So he has skin in the game to see this through to commercialization. If this works to dream status and the stock goes to $20 four or five years from now, he'll be worth $20 million, a fair reward for his genius - and something we can all benefit from, if it results in a safer more effective delivery of drugs to the brain.

Accurexa submitted its application for Small Business qualification to the FDA in preparation of the filing of our 510(k) marketing clearance application last week.

FDA Approves Accurexa's Small Business Qualification:

finance.yahoo.com/news/fda-approves-accu...

Great Technology Video (only nine minutes):

www.youtube.com/watch?v=zTrZ5QRUIkA&t=22

News Articles:

Devices Aim to Deliver on Stem-Cell Therapies.

www.nature.com/news/devices-aim-to-deliv...

It's Not Brain Surgery - Well it is for Accurexa and Dr. Daniel Lim.

www.bizjournals.com/sanfrancisco/blog/bi...

University of California Breaks out of the Lab.

www.bizjournals.com/sanfrancisco/feature...

Cell Transplantation Into the Brain With Radially Branched Deployment

www.nature.com/mt/journal/v23/n1/full/mt...

"New To The Street" to Air First of a 6 Part Series Featuring Accurexa.

This is the first installment of a six part series set to be aired nationwide to over 95 million homes on the History Channel.

finance.yahoo.com/news/street-air-first-...

Basic Financial Statistics.

Shares outstanding, 5.7 million as of 9/30/2014. Market value @ $2.50 - $14.2 million.

Cash & Equivalents, $748,000 (calling all investment bankers)

Of course they're a client.

==================================================

This release contains certain "forward-looking statements" relating to the business of the Company. All statements, other than statements of historical fact included herein are "forward-looking statements" including statements regarding: the ability of the Company to successfully develop and commercialize novel neurological therapies based on its BranchPoint device, ACX-31 and execute its business plan; the business strategy, plans, and objectives of the Company; and any other statements of non-historical information. These forward-looking statements are often identified by the use of forward-looking terminology such as "believes," "expects" or similar expressions and involve known and unknown risks and uncertainties. The Company's actual results could differ materially from those anticipated in these forward-looking statements as a result of a variety of factors, including those discussed in the Company's periodic reports that are filed with the Securities and Exchange Commission and available on its website (www.sec.gov). All forward-looking statements attributable to the Company or persons acting on its behalf are expressly qualified in their entirety by these factors. Other than as required under the securities laws, the Company does not assume any duty to update these forward-looking statements. Institutional Analyst Inc., publisher of the Stem Cell Stock Review has been compensated with twenty-thousand shares for IR services including providing ongoing coverage of their progress and reporting in both the Biotech and Stem Cell Stock Review.

Disclaimer: Important Distinction #1. First and foremost the Watch List is

just that. A watch list. It is not a buy list. Meaning that there will be

no buys or sales issued by the Reviews. If this was a buy

list, you can rest assured that we would crank up our Public Relations arm

into high gear, full speed ahead and damn the torpedoes to make everyone

know just how brilliant we were when we issued the list. Interviews on

CNBC, articles in Barron's and accolades in the Wall Street Journal--the

only thing we love more than money is praise and fame--but it just isn't

going to happen. What the Reviews are...is a "news

aggregation service". With the advent of the Internet, everyone knows what

that term means. What it means to us is the following: We will follow the

progress of as many Internet related publicly traded stocks as humanly

possible (The large, the small and the minuscule) and advise you of when

they have reported news. As a subscriber to the Reviews,

this means you will be able to broadly follow the entire industry right

from a single e-mail. We will report who released news and point (with

hyper links) to where the news can be found. We try to use Yahoo! Finance

as extensively as possible so we don't send you all over cyberspace. We

love Yahoo, you will too. Any decisions as to buy or sell however, are

strictly up to you. Which leads to important distinction #2. How do we get

paid? The Reviews are owned by a Public Relations firm

(Institutional Analyst Inc.) that specializes in getting (or creating)

coverage for publicly traded companies. As such, is important to note that

anytime we say anything about a company, it is because the company is a

client of our parent company, or because we would like them to be a client

of our parent company. In a nutshell, you can throw out any thoughts of us

being even a little bit impartial. It just ain't gonna happen. We love

everyone. Final note is we that have over 20,000 subscribers so please

excuse our dust. Institutional Analyst Inc. is an independent research and

investor-relations consulting firm that publishes investment-research

reports such as The Reviews on independently selected

companies. While it is its intent to identify and research companies that

it believes might prove to be profitable investments, The

Review is not liable for any investment decisions by its readers. Neither

The Reviews nor any report published by Institutional Analyst

Inc., represent a solicitation to buy or sell the securities discussed

within the report. It is strongly recommended that any purchase or sale

decisions be discussed with a financial adviser or broker prior to

completing any such purchase or sale decision. The information contained

herein is provided as an information service only and is based upon

sources deemed reliable, but not guaranteed by The Reviews.

Past performance of previously featured companies does not guarantee the

future success of any currently featured or mentioned company. The

information contained herein is subject to change without notice, and The

Reviews assumes no responsibility to update the information

in this or any report published. Use of this or any report published by

The Review may be subject to the applicable rules of

certain self-regulatory organizations and the securities mentioned herein,

which are traded Over The Counter, and may not be cleared for sale in

certain states. Institutional Analyst Inc and/or its employees, officers,

affiliates or members of their families may have long or short positions

in any of the securities discussed in this or other reports published

herein (and/or options or warrants relating thereto) and may purchase and

or sell these securities, options or warrants from time to time in the

open market or otherwise. Institutional Analyst Inc may derive

compensation through research services and subscriptions and/or

investor-relations consulting from the companies featured or mentioned in

its reports. Write or call Institutional Analyst Inc for disclosure

details as required by Rule 17b as it relates to individual issues.

Institutional Analyst Inc., In no event shall The

Reviews report be liable for direct, indirect, incidental or

consequential damages resulting from the use of this information. The

Reviews shall be indemnified and held harmless from any

actions, claims, proceedings or liabilities with respect to the

information herein. Institutional Analyst Inc is not a securities

broker-dealer, investment advisor or a securities exchange and is not

registered as such with the Securities and Exchange commission nor any

state securities regulation authority. Readers of this e-mail newsletter

should recognize that the Reviews are only providing a

delivery service to electronically transmit information to potential

investors. In this respect, the Reviews are no different than

the provider of any other delivery service such as the United States Post

Office or any other express delivery service. Accordingly, investors

should be aware that the Reviews have not evaluated nor

investigated any of the companies listed in this e-mail to determine their

merit or the risk of investment in any such company. The Reviews do not

endorse any company listed herein and the Reviews do not

represent that the information contained in any offering documents states

all material facts or does not omit a material fact necessary to make the

statements therein not misleading. institutionalanalyst@gmail.com

Disclosure: The author has no positions in any stocks mentioned, but may initiate a long position in ACXA over the next 72 hours.

Additional disclosure: See disclaimer