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$PVCT: Florey, Chain & Heatley

|Includes: Provectus Biopharmaceuticals, Inc. (PVCT)

Taken From Connecting The Dots...Provectus Pharmaceuticals (March 10, 2013).

Chemoablation via PV-10 Ablation Causes Antigenization

& Antigenization Causes Immunization

[I encourage you to click on the hyperlinks for certain words and phrases to attain more information on them.]

PV-10 causes antigenization. Antigenization causes immunization.

Antigenization is the expression of antigens, in a tumor into which PV-10 has been injected, in context. Immunization is "the process by which...[the] immune system becomes fortified against an agent."

PV-10 facilitates the relationship between antigenization and immunization.

Ablation: "In medicine, ablation is the same as removal of a part of biological tissue..." "Biological ablation is the removal of a biological structure or functionality."

Chemoblation: A process whereby cells undergo a form of cell death that mimics features of both necrosis and apoptosis.

PV-10 is an immuno-chemoablative agent.

The process of immunization (immuno-) is unlocked by PV-10 chemoablation (-chemoablative), which causes the rapid, durable necrosis of the tumor lesions.

PV-10 is both a metabolic agent (a chemoablative, and in the same general class as inhibitors) and also
an immunotherapeutic agent (in the same general class as immunomodulatory agents like ipilimumab, tremelimumab, PD-1, PD-L1, etc.).

PV-10 elicits cell destruction naturally; that is, apoptosis-like, which Provectus refers to as autolysis.

Unlike like necrosis, "which is a form of traumatic cell death that results from acute cellular injury,"apoptosis "is the process of programmed cell death." Autolysis, "more commonly known as self-digestion, refers to the destruction of a cell through the action of its own enzymes."

The key to PV-10 is diseased (cancerous) tissue cells are destroyed the way the body intended to destroy deficient or unnatural cells in the first place. PV-10 neither denature these cells nor changes their DNA.

The activity PV-10 induces in diseased cells causes antigenization, or the showering of antigens, whereby many, many, many antigens are shown to antigen presenting cells ("APCs"). These APCs then can choose which of the antigens to show (present) to the body's T cells, natural killer T("NKT") cells, Tumor-infiltrating lymphocytes ("TILs"), etc.

This work is done, thus, in situ, or in the tumor. Provectus and Moffitt Cancer Center have demonstrated PV-10 induces tumor-specific T cell-mediated immunity, and referred to the application of PV-10 as an in situ vaccination. PV-10 itself is the vaccine, or vaccination.

Induction: Bring about, initiating, increasing.

Immunity: "The state of having sufficient biological defences to avoid infection, disease, or other unwanted biological invasion."

Vaccination: "The administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen.

Is PV-10, itself, the "Holy Grail?"

Fareed Zakaria, in a December 10, 2012 interview on Fareed Zakaria GPS of Dr. Ronald DePinho, M.D., President of MD Anderson's cancer center, said "The holy grail for cancer would be to trigger the body's own immune system to fight off the cancer, so that you somehow stimulate the antibodies in a way that that happens." The treatment that is the holy grail for cancer is not the grail itself. Rather, the grail is what the treatment inspires, produces, engenders, induces, etc.: a strong, durable, portable immune-mediated response.

Does PV-10 immunize the treated patient against his or her cancer?

Immunization: The process by which an individual's immune system becomes fortified against an agent.

Is PV-10 an immunization for cancer? Is PV-10 the "penicillin for cancer?"

Only time can and will tell.

Peter is fond of saying the discovery process of PV-10 is akin to peeling back or away the layers of the onion. It appears to me the core of this onion is the actuality of PV-10 as an immunization for cancer. In this moment in time, the world is peeling away the layers in the direction of this, but it still is some distance from it.

"The development of penicillin for use as a medicine is attributed to the Australian Nobel laureate Howard Walter Florey, together with the German Nobel laureate Ernst Chain and the English biochemist Norman Heatley."

Disclosure: I am long PVCT.

Additional disclosure: I am a large shareholder of Provectus Pharmaceuticals, have not sold any shares as of this Instablog submission, and also author the blog "Connecting the dots...Provectus Pharmaceuticals."