Regen BioPharma Inc. Chairman Discusses the Rationale for Pursuing Autoimmune Indications by Activating the Nuclear Receptor NR2F6
NR2F6 is the Key to the Future
Focus Small Molecule
Focusing on Cancer & Auto Immune (Lupus)
Potential Buyout Target
SAN DIEGO, November 16, 2017
There are currently about 9 companies working on activating immune checkpoints, but Regen appears to be the sole company known to be working on utilizing small molecules to activate immune checkpoints (How immuno-oncology targets are spawning new therapies for inflammation).
18 months ago, Regen BioPharma Inc. (OTCQB:
RGBP)(OTCQB: RGBPP) commenced a program to identify small molecules that
inhibit the NR2F6 nuclear receptor. The NR2F6 nuclear receptor has been
identified as a potentially very important immune cell inhibitor (an immune
checkpoint) and cancer stem cell differentiator. Regen BioPharma believes
that by inhibiting the NR2F6 nuclear receptor, one can unleash the
cancer-killing potential of a patient's own immune system. Regen is also
engaged in the identification of small molecules which activate the NR2F6
nuclear receptor that can be utilized to develop small molecule therapies for
autoimmune disorders "The rationale for activating the NR2F6 nuclear
receptor (also known as a checkpoint) is straightforward - if inhibiting the
checkpoint activates the immune system and thus helps kill cancer cells, then
conversely, activating the checkpoint should suppress the immune system and
thus be useful in diseases where the immune system is over-activated, such as
rheumatoid arthritis, lupus, colitis and many other autoimmune diseases,"
says David Koos, Ph.D., Chairman and CEO of Regen. "Our program stands out because we are working with small molecules delivered in pill form.
Other biotechnology companies arefocused on antibodies that have much more cumbersome delivery methods (hospitalstays with IV injections, etc.). The benefits of small molecules are many, including cost of manufacturing, flexibility in dosing and routes of administration, potential control of toxicity and intellectual property protection."
About Regen BioPharma Inc.:
Regen BioPharma Inc. is a publicly traded biotechnology company (OTCQB: OTCQB:RGBP) and (OTCQB: RGBPP). The Company is focused on the immunology and immunotherapy space. The Company is focused on rapidly advancing novel technologies through pre-clinical and Phase I/ II clinical trials. Currently, the Company is focused on small molecule therapies for treating cancer and autoimmune disorders. Additional information on Regen BioPharma is available at http://www.regenbiopharmainc.com
Regen BioPharma, Inc. Announces Former Eli Lilly Executive And Current CVS Board Member Will Lead Newly Formed Business Advisory BoardRegen BioPharma, Inc. Begins Program to Determine the 3-Dimensional Crystal Structure of NR2F6
Structures with &Without Small Molecules to be DeterminedRegen BioPharma, Inc. Researchers Capitalize on Key Structure in Compounds that Activate Checkpoint NR2F6 for the Potential Treatment of Autoimmune Diseases
Key Partners – Eli Lily & Company – Chem Div
We believe Regen BioPharma is a Long Play, with a great upside with all the items in its Pipeline. Very possibly a Buy Out Target.
RGBP also has Short Term Gain Potential that has recently moved up near 106%. Moving from $.036 on 11/9/17 to Closing today @ $0.074. Increased liquidity has been present as well.
If you have any questions concerning (OTCQB:RGBP) or have a need for more information, please feel free to contact me.
Robert E. Kreh - Principal
Small Cap Solutions, LLC
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