The History of Anatabloc
Although I don't know the full story or the sequence of events, it is my belief that Star Scientific (STSI) accidentally stumbled upon the anti-inflammatory properties of Anatabine (a minor alkaloid in tobacco and other plants we eat every day such as tomatoes, eggplants, and peppers). Anatabine is similar in chemical structure to Nicotine, but it has entirely different biochemical properties. In fact, Star has been selling an Anatabine based product called CIGRx for the past four years as a smoking cessation product, and it apparently has some ability to curb the urge to smoke brought on by nicotine addiction. Star has been granted a patent by the US Patent and Trademark Office for the artificial synthesis of Anatabine, so it is made in a lab (not extracted from tobacco). The lab synthesized version is almost 100% pure and this is the active ingredient in Anatabloc.
Star has also filed numerous patents for the anti-inflammatory applications of Anatabine in humans, especially as they relate to stopping the transcription of Nuclear Factor-kappa B (NF-kB). This is an early step in the JAK STAT inflammation pathway, and it is best understood by watching this video and reading this link. It should be noted that nutraceuticals can be patented for specific diseases, and Star has filed a multitude of patent applications, both at the USPTO and at the World Intellectual Property Organization (WIPO). In addition, this press release reveals that Star has filed a patent for the S-(-) isomer of Anatabine, which is not found in nature. This isomer (or enantiomer) would be the basis for a prescription version of Anatabine. You may note this was filed over two years ago, so we should be nearing a time when the patent could be granted. This same press release linked above was the first time Star Scientific publicly stated they are seeking teaming partners from big Pharma (see the 4th paragraph).
My Personal Experiences with Anatabloc
I am a huge proponent of Anatabloc because of my personal experiences and the personal experiences of people I know who have taken Anatabloc for a variety of ailments, from Rheumatoid Arthritis to Crohn's Disease, and from Multiple Sclerosis to Alzheimer's Disease. I am going to focus this article on my personal experiences, but I will share a few anecdotal stories of others who have used Anatabloc. First, it might be beneficial to read the testimonials of other Anatabloc users on the GNC Website and on Amazon.
I have been taking Anatabine Citrate for almost two years now. I started with CIGRx in July 2011, and then started taking Anatabloc in September of 2011, shortly after it became available and I received my first shipment. I am a former athlete now in my mid 50's and I am a big guy (6'4", 275 lbs). I have both bronchial asthma and Rheumatoid Arthritis (NYSE:RA), along with a host of other aches and pains that come with having sports injuries, being sedentary, being in my mid 50's and being overweight. At one time my weight had ballooned to about 315 lbs. It was about this time when I started increasing my Anatabloc dosage from 6/day to 12/day and I noticed that my appetite seemed to be curbed (especially my tendency to snack late at night) and without even realizing it I was starting to gradually drop some weight (about 40 pounds in six months).
I have had bronchial asthma since I was a child. It was mostly in remission in my teens and 20's, but reappeared in my 30's. I was diagnosed with rheumatoid arthritis about 15 years ago. For my bronchial asthma, I have always taken Singulair along with Albuterol inhalers, with occasional rounds of prednisone when I had a bad asthma attack. Before I started taking Anatabloc, I used the Albuterol inhalers extensively (12-16 puffs/day) and several times per year I would have to take steroids (prednisone or methylprednisone dose packs) to recover from asthma attacks. Over the years, I have taken a variety of the new RA biologic drugs (Remicade, Enbrel, and Humira) along with Methrotrexate. I had a reaction to Remicade once when I was getting a transfusion, so Remicade was out for me and it was between Enbrel and Humira. Humira seemed to work best for me, and I have now been on that drug for over 9 years. When I first started taking Humira, I was taking it every two weeks, but my RA became so bad, my rheumatologist changed my Rx to every week. In 2010 and early 2011, a combination of weekly Humira injections (I gave myself) along with Methotrexate had my RA under control. About my only limitation was that my finger joints would become inflamed after I played golf, and I would not be able to play golf again for several days until the inflammation subsided. This prevented me from going on annual golf trips with my friends where we played 4 or 5 days in a row (sometimes 36 holes/day).
All this was before I learned about Anatabine Citrate which has changed my life, just like it changed the life of Cheryl Riley as seen in this CBS local news piece. I have recommended Anatabloc to well over 100 people over the past two years, and the vast majority have seen benefits and continue to take it (I'd estimate over 80%). My suspicion now is that people who didn't observe the benefits either did not take a high enough dosage (6/day is not enough for some people to observe the benefits), or they did not properly space their dosages out during the day. To receive the maximum benefit from Anatabloc, you need to determine the right daily dosage for yourself, and you need to take it about every 5-6 hours. After two years, I have adjusted my dosage to 20/day (I was still having some RA problems at 16/day when I stopped taking Methrotrexate and Humira, so I needed 20/day). I take 4 doses of 5 Anatabloc tablets at 6am, noon, 6pm, and 11pm. You might note this is above the maximum dosage recommended on the label, but it is what I have found works best for me via trial and error. This is the dosage that allows me to stop taking my Rx medications for Asthma and RA.
As a result of taking Anatabloc, and gradually increasing my dosages, I have been able to almost completely wean myself off of all prescription medications, which I view as a major success. When I was taking 6 Anatabloc per day in the fall of 2011, I noticed I no longer needed my Albuterol inhaler, so I stopped refilling that prescription in early 2012. I also noticed I no longer needed to take Humira weekly, so I changed to every 2 weeks (with the concurrence of my rheumatologist). During this period of time I was having lab work done on a monthly basis because I was taking Methrotrexate, so I not only had my liver function results, I also had my CRP levels tested (and they were consistently <.5). Powerful biologic drugs (like Enbrel and Humira) weaken your immune system, and can have detrimental effects on your liver and other organs (listen to the disclaimers on the TV ads). So, I was striving to minimize my frequency of taking these powerful drugs due to side effects and I also wanted to reduce my overall healthcare costs because the monthly co-pays on the Rx drugs added up.
By increasing my dosage of Anatabloc, I was able to gradually reduce my Methrotrexate dosage (from 20 mg per week to zero) and I was able to stretch my Humira injections out to once per month and now once every six weeks (and my hope is to completely stop Humira this summer). So, you can see why I am ecstatic about Anatabloc. I have almost completely weaned myself off of all my Rx drugs for Asthma and RA (and seasonal allergies), and I am just taking Anatabloc. My Rheumatologist wrote me a prescription for Anatabloc so I can pay for it out of my Flexible Spending Account at work (you can do this with OTC drugs with a Doctor's prescription). My Humira alone costs me a $50 co-pay per prescription (and I think the total cost of Humira for the insurance company is >20K/year if taken every 2 weeks). So, you can see, Anatabloc has a significant potential to reduce healthcare costs. The benefits I have observed from Anatabloc's ability to ameliorate the symptoms from Asthma and RA are more than enough to justify it for me, but I have also observed the following additional benefits:
1. My knees no longer ache. I have had three surgeries from football injuries (one ACL repair and two meniscus repairs). I was used to having aches and pains, especially when I woke up in the morning. After taking Anatabloc, that is a thing of the past.
2. I breathe better and sleep better. I'm not sure why, but it may be because Anatabloc reduces inflammation of the air passageways. I am assuming it reduces the inflammation in my sinuses and my lungs so I can breathe deeper and which allows better O2 absorption.
3. I urinate better. Every male I know who is over 40 who has taken Anatabloc has observed this same benefit. I would conservatively estimate my urine stream is about 5 times stronger than it was before Anatabloc. Remember when you were young and you could "piss a rope"? Well, you can enjoy that feeling again with Anatabloc.
4. My mental acuity seems sharper. I no longer forget various passwords (which is easy to do when you have a dozen or more). I also remember several 16 digit credit card numbers I use for hotel and airline reservations.
5. I no longer need reading glasses or contact lenses. I have had contacts since my 20's for myopia and after I reached my mid 40's I also needed reading glasses (was using a 1.5 or 1.75). I noticed after about 4-6 months on Anatabloc, I no longer need my reading glasses (but still needed my contacts). After a few months on higher dosages of Anatabloc, I noticed I no longer even needed my contacts. I had my vision tested about 3 months ago and I was 20/25 in each eye, whereas before I was about 20/200 (uncorrected). I still have a little astigmatism, but I no longer need reading glasses or contact lenses for driving (even at night). My opthamologist thinks I am a freak of nature…I think it is the Anatabloc.
6. The age spots (some call them liver spots) on the back of hands are almost completely gone. I think this was a combination of using Anatabloc lozenges and a "free sample" of the skin crème. I'm looking forward to Star Scientific announcing the clinical trial results of the Anatabloc skin cream on Rosacia. FWIW, I think this product will eventually become a huge seller, as I think there will finally be a wrinkle cream that really works. When people see the results, the skin crème products should become a popular alternative for women who get facelifts and Botox treatments, because Anatabloc seems to work great on wrinkles (and no one can tell you "have had some work done" because it looks natural). This should eventually be a very profitable product for Star.
7. I have a general feeling of well being. I don't know exactly how to describe it, but things that used to bother me and make me worry (mostly job related stresses), no longer seem to bother me as much. It's pretty much what Fred Couples said in this interview (linked below)….. "I don't even know how to explain it, I just feel much better." You have to turn up the volume to the max in this short Fred Couples Youtube video. Former professional tennis players (Jimmy Arias, Aaron Krickstein, etc.) also had similar benefits as did John Isner. You might also be interested in the comments by world famous male model Brad Koenig.
8. My libido has been greatly enhanced. Without getting into any details, I think most men will see significant improvements in this area.
9. It seems to curb my late night tendency to snack. I have lost about 40 pounds since I upped my Anatabloc dosage. It seems to have some type of effect on the brain to stop food cravings (especially carbs).
10. I wake up each morning feeling refreshed and ready for the day. This somewhat goes along with #2 and #7 above.
The above list of benefits are what I have personally observed. IMHO, Anatabloc really does "turn back the clock" as Star says in the Fred Couples ad campaign. I feel like I am in my mid 30's instead of my mid-50's. I travel all over the country on business, and I share my Anatabloc results with every GNC sales associate I meet when I visit a store. A few GNC employees are skeptical when I tell them about my experiences...but those are typically the ones in rural stores that haven't sold much Anatabloc. In the big city stores (where Anatabloc is flying off the shelves), the associates have heard similar testimonials to my experiences and they believe in the product.
IMHO, as the word of the benefits of Anatabloc starts to spread, GNC will see a whole new class of customers entering their stores. GNC has historically catered to the fitness oriented and body building crowd (many of whom are now taking Anatabloc to improve their workouts and endurance as it apparently helps with delayed onset muscle soreness aka DOMS). In my recent GNC store visits, sales associates have told me that they are now starting to see middle aged and elderly folks frequenting their stores and asking for Anatabloc (as it is a proverbial fountain of youth). Right now GNC is the only brick and mortar store where you can buy Anatabloc, but I hope that will change later this year after peer reviewed results are published. I would like to see it offered in a few major drugstore chains (Walgreens and CVS) and maybe even in WalMart or Target.
This brings me to some of my friends who take Anatabloc. While I don't mind getting into details of my own personal health experiences, I hesitate to offer the same level of details on others I know, so I am going to relate some generic observations of some friends and acquaintances who take Anatabloc. I have one friend who takes Anatabloc for MS. Before taking Anatabloc, she was walking with a brace on one leg and with a cane and I had watched her deteriorate on a monthly basis. She has now been on Anatabloc for about a year and she no longer has to use a brace or a cane, and she says her pain and discomfort levels are significantly reduced. She is only taking 6-8/day, and I think she would improve even more if she doubled her dose, but cost is a factor. I have another friend in her 20's that Anatabloc has completely changed her life, as she is taking 6/day and her Crohn's disease is in complete remission. I have three friends with parents in their 70's and 80's with Alzheimer's. They are giving their parents Anatabloc (the standard dosage based on the new recommendations on the bottle). Two of them have noticed significant improvements in memory such as recognizing family members and remembering the names of nursing home staff, where before Anatabloc supplementation, they had no idea who they were. One AD patient has lost most of her memory and she has not shown any improvement, so my observation is that the earlier in the disease one can take the product, the more beneficial it will be. I am anxiously awaiting the results of the human Alzheimer's clinical trial being conducted by Roskamp Institute.
I have numerous friends that have Osteoarthritis (knee pains, back pains, shoulder pain, swollen hands and fingers, etc.) and almost all of them see significant benefits from Anatabloc. I have a friend who suffered from Plantar Fasciitis for months, but with Anatabloc, it was gone in three days. I have friends with testimonials for Anatabloc (and Anatabloc skin crème) including ailments such as periodontal disease, migraines, depression, psoriasis, eczema, rosacia, fibromyalgia, celiac disease, etc. I even have two friends who are giving it to their dogs, and a dog that is 14 with arthritis is now able to jump up on the couch (after not being able to do so for over a year). There are four human clinical trials on-going with Anatabloc that can be found here. I expect the peer reviewed results on two (possibly three) to be out this year.
As noted earlier, Star released a PR that they are pursuing teaming agreements with big Pharma. I think big Pharma wants to know how it works which is called the Mechanism of Action (MOA). These comments about the MOA were in their last 10-Q, so it is my hope this information will be coming out soon.
In 2013 Rock Creek received positive results from a study conducted by researchers at the University of Virginia Medical School investigating the effects of Anatabine in an animal model of idiopathic inflammatory bowel disease, ulcerative colitis. It also received functional binding data that offers an explanation and a possible mechanism of action for some of the observed effects of Anatabloc ®.
As the clinical trials on Anatabine Citrate (Anatabloc) are completed and the results are reported, I think word of mouth will spread like wildfire. In some places (like FL and AZ retirement communities), GNC stores are selling Anatabloc as fast as they can get it in. Anatabloc should get a lot of free press after the peer reviewed results are published, which I expect to come out later this year (possibly in the next few months). After studies are published, I think the doctors will be free to appear on healthcare related TV and radio shows to discuss chronic inflammation and how Anatabloc works to alleviate that condition.
With STSI stock currently selling below $2, now would be a very opportune time to accumulate shares. If Star breaks through the recent high of $1.63 in the next week or two, I think this will be the start of an extended upward run. It took ten months for STSI to drop from above $5 to below $1.20, but I suspect it will take well less than 4 months for it to return to the $5 level, especially if positive news breaks.
When STSI Makes a Run....it can run quickly so don't miss it. Back in March 2011, STSI (then CIGX) went from a low of $1.78 to a high of $5.12 in just 22 trading days. I think it needs to break through $1.63 (on high volume), but after that it could be a repeat of what happened in March 2011. For whatever reason, this just seems to be the way STSI trades. For example, on Aug 2nd 2008, Star went from $1.60 to $4.19 in ten trading days. On March 5th 2010, it went from $1.02 to an intraday high of $3.69 in 22 trading days.
Over the past 6 months, STSI has seen a lot of negative press. There have been class action suits filed from their alleged misrepresentation of their relationship with Johns Hopkins Medical School. The ASAP clinical trial on thyroiditis listed on clinicaltrials.gov clearly stated where the testing was being done, and, although some people outside the company reported it was being done at Johns Hopkins, the only connection was that Dr. Paul Ladenson, the Head of Johns Hopkins Dept. of Endocrinology and Metabolism, was serving as a consultant to STSI. To the best of my knowledge after scouring the Star Press Releases, I never found any place where they stated the ASAP study was being done at Hopkins, so I think the class action suits against STSI are a long shot at best. In fact, there could even be countersuits filed by STSI against these firms for filing frivolous securities lawsuits, if it is proven that the charges are baseless, and they failed to do their due diligence before filing these suits.
Another negative that has helped to drive the stock down to current levels is related to the CEO's campaign contributions to Republicans in Virginia. While this concerns some investors, I look at it as an opportunity, because the price has been driven down relentlessly and does not adequately reflect the potential upside that might occur if only one or two of the human ailments I have listed can be treated with Anatabloc. It is my belief that at a minimum, Anatabloc will help a lot of people with autoimmune diseases associated with chronic inflammation. At a maximum, it is a world changing nutraceutical (with a patent pending for a prescription version) that could change the face of medicine.
Good Luck to all STSI Longs.
Disclosure: I am long STSI. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article.
Additional disclosure: I have taken the product for almost two years and I know it works for me and many of my friends.