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Wired Magazine Article, Cytori Therapeutics (CYTX)

Wired Magazine published an excellent article last week documenting the progress of Cytori Therapeutics as they develop methods for breast surgery using “adipose-derived stem cell fat grafting.”

Using fat grafts and stem cells taken from adipose tissue, a woman could undergo breast or breast reconstruction using her own natural tissue – not an implant. At least that’s the hypothesis behind much of Cytori’s research and development of their Celution system.

How does it work?

  • The fat cells provide increased volume while the regenerative cells within the mixture encourage growth of the blood supply, allowing the fat graft to survive in the breast;
  • But “breasts are just the beginning,” says the article – a must … BUY … magazine;
  • The technology has potential in many other regenerative therapies for different organs. And the stem cells are readily available in body fat, the same fat that’s typically removed during liposuction;
  • Wired: http://www.wired.com/magazine/2010/10/ff_futureofbreasts/

According to Wired, “regulators in Europe and Japan were satisfied with the animal and human studies Cytori submitted for approval of the Celution machine, “but the US FDA has not given their approval for the device.

“But breast augmentation is just one development (so to speak) in the company’s more ambitious plan: to introduce stem cell medicine to the mass market—and not using the ethically fraught kind of stem cells from human embryos. Instead, based on almost a decade of trials that Cytori and its academic partners have performed on cell cultures, lab rodents, and now humans, they believe their engineered flab cells can treat more organs than you find in a French butcher shop.

  • Chronic heart disease? Check: In human studies released in May, the cells improved patients’ aerobic capacity and shrank the size of the infarct (tissue killed by lack of blood).
  • Heart attack? Check: A human clinical trial, also reported in May, found that the cells increased both the blood supply to damaged heart muscle and the volume of blood that the heart pumped.
  • Kidney injury as a result of cancer therapy? Check: In recent rat studies, the cells improved kidney function.
  • After prostatectomy? Check: Another recent study reported that, by 12 weeks after injection, the cells had decreased the amount of urine male volunteers were leaking by 89%.

If Calhoun and his scientists succeed, they won’t just create more cleavage. They’ll make practical a whole new field, one that medical visionaries have dreamed of for decades: regenerative medicine”. Great article – (Sharon Begley, Wired November 2010)