Data provides insight into Anti-inflammatory Mechanism of PRP …
CMXI presented positive data on the Angel® cPRP system in a veterinary application - treatment of persistent mating induced endometritis (PMIE) in mares at the 3rd annual conference of the North American Veterinary Regenerative Medicine Association (NAVRMA) in Savannah, GA.
Treatment with PRP was shown to be associated with a statistically significant reduction in certain endometrial pro-inflammatory cytokines and inducible nitric oxide synthetase (iNOS), both known to be involved in the pathology of PMIE.
The Bottom Line: Infertility in high value mares is a significant economic problem in the equestrian industry. Intra uterine treatment with PRP offers a new approach to treating this condition; multiple pregnancies were observed in the treated mares that were previously barren. Use of PRP in this setting warrants further investigation. Many mares fail to respond to conventional therapies and recent studies have shown a link between PMIE and the expression of certain cytokines. The study investigated 9 barren mares with a history of PMIE. During the treatment cycle, whole blood was processed using the Angel cPRP system and the resultant PRP was brought to a final volume with platelet poor plasma and infused into the uterus. These results are very promising and give further insight into the mechanism by which PRP inhibits inflammation by decreasing the presence of pro-inflammatory cytokines.
The equine market is often under-appreciated as an important part of the animal health market. There are approximately 10.5 M horses in the US, and their owners <approximately 2 - 3 M> are willing to spend "unlimited" amounts of money on their health care, to the tune of several hundred million dollars. These horses are responsible for generating over $40 B per year in spending. Having been the other half of an equestrian with an 18 year "relationship" with the thoroughbred "Ben"; I understand the costs, care and impact of the equine market. This is a market CMXI should further channel!
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