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iPS Cell Patents, Advanced Cell Technology (ACTC.OB)

Aug. 17, 2010 9:53 AM ET
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ACTC.OB is now positioned to obtain significant patents relating to cellular reprogramming and the generations of induced pluripotent stem (iPS) cells. iPS cells are similar to embryonic stem (ES) cells, except they are generated from adult cells – such as skin − using certain reprogramming factors, without the controversial use of embryos.

Although human iPS cells were first produced in 2007, ACT has been working on inducing pluripotency, with positive results, for more than a decade back to the 1990s, providing (through existing patent filings and continuations) some of the earliest priority dates in the field.

  • ACT scientists and other showed that adult somatic cells could be reprogrammed back to a pluripotent state using somatic cell nuclear transfer (SCNT);
  • In 2006, Yamanaka and colleagues reported a new and less controversial method of reprogramming somatic cells to pluripotency using viral expression of transcription factors (Oct4, Sox2, Klf4, and c-Myc);
  • Subsequent studies confirmed that human cells could also be reprogrammed to the pluripotent state using similar reprogramming factors;
  • Unfortunately, these cells are unsuitable for human clinical use since the use of genome-integrating viruses could cause mutagenesis and unpredictable genetic dysfunction.

Earlier this year, a number of groups, including scientists at ACT, showed that a range of therapeutic cell types obtained from iPS cells exhibit abnormal expansion and early aging.

  • The research compared a variety of replacement cell types derived from human induced pluripotent stem cells (iPSCs) to their embryonic stem (ES) cell counterparts;
  • The research showed that the iPSCs can generate blood, vascular and retinal cells with characteristics similar to those from ES cells, but with a dramatically decreased efficiency.

ACT is pursuing claims (published and unpublished) that, if granted, would dominate the use of what the rest of the research community is now coming to understand are the key regulators of induced pluripotency.

  • “With a very strong intellectual property portfolio in place, including a recently-issued broad patent for production of retinal pigment epithelial cells, we are continuing to pursue an aggressive patent filing strategy. We have filed multiple patent applications to cover reagents and processes related to induced pluripotency, as well as the resulting cell compositions. Importantly, we do not want to impede the development of iPS cell research by others in this field, and prefer to work cooperatively to stimulate innovation and to help to drive the realization of iPS cell technology for new therapies” said William M. Caldwell IV, the Company’s Chairman and CEO.

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