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Rayno Life Science Stocks-ASH Update-2 GILD, PCYC, SGEN

Weak Tape Today 12/10--Gilead (NASDAQ:GILD) Down 4.4% on 15.5M Shares

IBB ($218.81) down 1.33%% on good volume. Could be reaction to Abbvie (ABBV $53.55) up 4.5% on Phase 3 Hepatitis C data. Virologic response of ABT-450r is 96% in Genotype 1 patients.

Other weak Rayno Biopharma stocks: Alexion (NASDAQ:ALXN) down 1.27%, Regeneron (NASDAQ:REGN) down 1.4%, and Vertex (NASDAQ:VRTX) down 1.7%. Our mid-cap index is also weak down 1.5% with sell-off pronounced in ALNY, CLDX, GERN, MDVN, PDLI and PBYI.



Choppy Action After Hitting New Highs

ASH Meeting Movers-Targeted Therapies for Leukemia Without Chemotherapy

Rayno Biopharma Stocks-Sell On News?

Gilead (GILD $74.91) up 1.23%

Gilead announced pivotal Phase 2 data for idelalisib, an oral inhibitor of P13k delta, in refractory indolent Hodgkin's lymphoma with a 57% overall response rate.

Seattle Genetics (SGEN $41.37) off 7%

Seattle Genetics stock sold off after presenting long term follow-up Phase 2 survival data on ADCETRIS for relapsed or refractory Hodgkin lymphoma. Median survival of 40.5 months and three year survival rate of 63%. A Phase 1 trial for an ADC (SGN-CD19A) was also presented for ALL (acute lymphoblastic leukemia).SGEN was added to our portfolio on 2/9/09 at a price of $9.50 so take some profits after a 4X return.

Pharmacyclics (PCYC $119.64) off 6.3%

Data presented on Sunday from Pharmacyclics supported high expectations for IPI-145 (ibrutinib) for CLL (chronic lymphocytic leukemia). After 12 months a study showed 6/8 patients had no cancer.An FDA decision is expected by end of February for CLL. The drug is already approved for mantle cell lymphoma. 2019 revenues for ibrutinib are forecasted at $4.7B.

Biogen (BIIB $286) off 1.63%, Immunogen (IMGN $14.83 ) off 0.67%, Regeneron (REGN $278) off 1.8%

ETFs were weak IBB off 0.5%, PBE off 0.6% XBI off 1.38%

Rayno DX and Tools Stocks 11/10 Update

Nanostring strong again today up 4.6% to $14.22. Hologic(NASDAQ:HOLX) up 0.4% to $22.20.Accumulate HOLX for long term. Illumina (ILMN $99.76) off 1.5% after closing above $100.

Notable movers are Alere (ALR $33.42) up 2%, Hologic (HOLX $22) down 1%, Illumina (ILMN $101) up 1.76% and Nanostring (NSTG $13.70) up 2%

Disclosure: I am long NSTG, HOLX.

Additional disclosure: long FBIOX