Please Note: Blog posts are not selected, edited or screened by Seeking Alpha editors.

Could Glaxo smith klin crater under the weight of AZT?

|Includes: GlaxoSmithKline (GSK)

Is it possiable that one deadly drug could take down an entire company?

This movie could be the start and the end!

house of numbers

http://www.youtube.com/watch?v=X_N4zgjF0K0

AZT is a cytotoxic chemical, a "DNA chain terminator." It interferes with DNA replication, by substituting itself for thymine, one of the base components in the DNA chain. This, theoretically, interferes with the reproduction of HIV. But it also interferes with the reproduction of the T-cell, the basis of the immune system, and the T-cell dies. The doctors who tested AZT for its effectiveness against HIV claimed they found that AZT was one thousand times as toxic to HIV reproduction as it was to the T-cells that were involved in that reproduction

A 1999 study in the journal AIDS reported that children born to mothers who are given AZT are sicker and die faster than those not given the drug. It is one of several recent studies reporting that AZT increases the rate of illness, major malformation and death in children whose mothers are fed the drug.

“RPD [rapid disease progression] was three times more likely to occur in infants born to [AZT] treated mothers- compared with findings in untreated mothers.”
de Souza RS et al. Effect of prenatal zidovudine on disease progression in perinatally HIV-1-infected infants. J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):154-161

"Macaques AZT-exposed infants were mildly anemic at birth. AZT caused deficits in growth, rooting and snouting reflexes, and the ability to fixate and follow near stimuli visually"
Ha JC et al. Fetal, infant, and maternal toxicity of zidovudine (azidothymidine) administered throughout pregnancy in Macaca nemestrina. J Acquir Immune Defic Syndr. 1998 May 1;18(1):27-38

"AZT-exposed infants took three times as many sessions as controls to meet criterion on Black-White Learning, a simple discrimination task"
Ha JC et al. Fetal toxicity of zidovudine (azidothymidine) in Macaca nemestrina: preliminary observations. J Acquir Immune Defic Syndr. 1994;7(2):154-7

Finally, in 1995, the "father" of AZT prophylaxis, Paul Volberding, wrote : "Zidovudine [AZT]...does not significantly prolong either AIDS-free or overall survival.

Ouch!