CytRx Corporation (NASDAQ:CYTR) announced today that results from a series of preclinical studies show that bafetinib may be useful in preventing bone loss in cancer patients who are at high risk for this event. The studies, which evaluated the effect of bafetinib on bone cells (osteoclasts) from multiple myeloma patients, were directed by leading multiple myeloma expert James R. Berenson, MD, Medical & Scientific Director of the Institute for Myeloma & Bone Cancer Research.
The studies demonstrated that in two model systems, bafetinib significantly suppressed the activity of osteoclasts and inhibited bone resorption in a dose-dependent manner, which is the process by which bone cells known as osteoclasts break down bone. Bone formation and bone resorption are closely coupled processes involved in the normal remodeling of bone. In patients with bone metastases, increased bone resorption can outpace bone remodeling, causing bone deterioration.
Dr. Berenson stated, “The consequences of bone loss in cancer patients due to increased bone resorption can be devastating, including fractures, bone pain and hypercalcemia. Prior studies indicated that Lyn and Fyn kinases have negative impacts on osteoclasts, thus potentially reducing bone resorption, which prompted us to evaluate bafetinib’s osteoclast inhibitory activity in bone deterioration using cells from multiple myeloma patients. We are encouraged by the results.”
CytRx President and CEO Steven A. Kriegsman said, “Results from these first-ever studies evaluating bafetinib’s anti-bone resorptive effects showed that this kinase inhibitor could present a new therapeutic option to reduce skeletal complications in cancer patients. Reduction of bone loss represents one of multiple oncology indications in which bafetinib could represent an effective treatment.”
CytRx is currently evaluating bafetinib in three ongoing clinical trials: the PROACT Phase 2 proof-of-concept prostate cancer clinical trial in patients with advanced cancers; the ENABLE Phase 2 proof-of-concept clinical trial in patients with a late-stage form of leukemia known as high-risk B-cell chronic lymphocytic leukemia; and a pharmacokinetic clinical trial in patients with recurrent brain tumors.
CytRx holds rights to bafetinib (formerly known as INNO-406) in all territories except Japan. Bafetinib is a potent, orally available, rationally designed, dual Bcr-Abl and Lyn kinase inhibitor, which was developed as a third-line treatment for patients with CML and certain forms of acute myeloid leukemia (AML) that are refractory or intolerant of other approved treatments.
CytRx Corporation is a biopharmaceutical research and development oncology company engaged in the development of high-value human therapeutics. The CytRx oncology pipeline includes three programs in clinical development for cancer indications: bafetinib, tamibarotene and INNO-206. The company was founded in 1985 and is headquartered in Los Angeles, California.
Crown Equity Holdings Inc. (OTCPK:CRWE)
Crown Equity Holdings Inc. announces that it has extended its CRWENEWSWIRE global platform web presence and is now publishing online news and information to the following countries: Argentina, Australia, Brazil, Canada, China, France, Germany, India, Ireland, Italy, Japan, Malaysia, Mexico, New Zealand, Russia, Singapore, South Africa, South Korea, Spain, Taiwan, United Arab Emirates and the United Kingdom, using their specific country code domain and native language.
“In addition to publishing to the mentioned countries, Crown Equity Holdings Inc. has also established online publishing sites for over 660 various cities within those countries,” stated Arnulfo Saucedo-Bardan, Chairman of the Board for CRWE.
CRWE has also established over 1,100 city specific sites within the US, allowing CRWE to publish its news and information globally or geographically.
“This increases Crown Equity Holdings Inc. online network, which already receives more than 510,000 pages views per month, during its 357,000 visits from over 250,000 people according to a third party media measurement service provider Quantcast,” stated Kenneth Bosket, President of CRWE.
CRWE’s wholly owned subsidiary, Crown Tele Services Inc., has completed installing servers for its business, which is currently in the process of preparing to provide and offer its “VoIP” communication services to small, large and enterprise businesses.
In other company news, Crown Equity Holdings Inc. announced recently that its subsidiary company, Crown Tele Services Inc. (http://www.crownteleservices.com) is still moving forward after dissolving its joint venture with Communication Expert Corporation and will gradually start rolling out its internet based voice and video service IP-PBX solutions this year.
The cornerstone of Crown Tele Services Inc. strategy is to meet the highest standards when it comes to delivering VoIP (Voice over Internet Protocol) communication solutions specifically designed to meet the market needs.
Proper Power & Energy, Inc. (OTC:PPWE)
In Kentucky, Oil and gas are produced from more than 1,500 pools from rocks of Cambrian to Pennsylvanian age. Most oil is produced from Mississippian limestone and sandstone in eastern and western Kentucky or from Ordovician limestone and dolomites in southern Kentucky. Most natural gas is produced from the Devonian black shale in eastern Kentucky.
Kentucky’s existing oil and gas infrastructure is extensive. Exploration and production costs are low due to the occurrence of shallow resources. Kentucky is centrally located for access and distribution to northern and eastern industrial markets.
Many farmers in Kentucky are trading in their tractors and overalls for oil derricks and wildcatting gear. With the price of oil reaching an all time high and the family farm becoming more and more obsolete, the attraction of getting rich by striking oil on the family's back forty is becoming harder and harder to resist. And not without promise, current geological readings estimate that nearly five billion barrels of oil reserves could be tucked away near Kentucky's famed coal mines of old.
PPWE has begun production on its Kentucky oil asset, in addition to the 11,000 acres leased for its exploratory prospect in Utah. The Utah prospect has the potential for over 75 wells. PPWE believes the Utah property holds very substantial recoverable reserves, indicated through seismic and radiometric analysis.
Utah ranked 11th in the United States in crude oil proved reserves and 8th in natural gas proved reserves (not including Federal Offshore areas) in 2008.
Utah ranked 13th in the United States in crude oil production and 9th in gross natural gas production (not including Federal Offshore areas) during 2008.
Utah contains four of the Nation's 100 largest oil fields, two of its 100 largest natural gas fields (2008).
Utah has approximately 3,200 producing oil wells and 5,700 producing natural gas wells.
Proper Power & Energy, Inc. maintains 10,000 plus acres of leased land in Central Utah, and last year announced the results of its initial review of seismic data. This was on the heels of Thrust Resources' Radiometrics Plus data suggesting the existence of huge pay zones in the Valley.
About Proper Power & Energy:
Proper Power & Energy, Inc. is an independent exploration and production company. PPWE's operations are in Kentucky, which provides for low risk developmental drilling and production, and Utah, which PPWE controls over 11,000 acres for its exploratory prospect. Renowned geophysicist and consultant to PPWE, Robert Dunbar, believes the Utah prospect could hold up to one billion barrels of recoverable oil.
To learn more about PPWE visit: http://properpower.com
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