ISIS, PPWE, KEYW, MJS.V, AFCE - Market Update From DrStockPick.com!

Isis Pharmaceuticals, Inc. (Nasdaq:ISIS) announced that it will hold a conference call focused on Genzyme's recent regulatory discussions with the FDA about the mipomersen NDA filing. Genzyme plans to communicate at its JP Morgan presentation Tuesday that: It had a productive meeting with the FDA. Based on FDA feedback, it believes the mipomersen package for HoFH is sufficient for filing. Due to the size of the severe HeFH population, the FDA provided guidance for additional 12 month exposure data before the mipomersen filing for severe HeFH. The Genzyme team is working with the FDA to further define the study required. FDA acknowledged that an outcome study may not be feasible in severe HeFH patients due to the size of the population.

Isis Pharmaceuticals, Inc. engages in the discovery and development of a new class of drugs called antisense drugs using antisense technology, a novel drug discovery platform to generate a broad pipeline of first-in-class drugs.

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Proper Power & Energy, Inc. (OTC Bulletin Board:PPWE.ob) has restructured its executive management team and entered into a strategic alliance.

Andrew J. Kacic will replace Joseph Abdo as President of Proper Power & Energy. Mr. Kacic brings more than 32 years of progressive experience as a chief executive in oil and gas, investment banking, insurance services and public securities. Mr. Kacic was the founder and president of American Resources of Delaware, Inc. and its subsidiary Southern Gas Company, successfully taking assets from $220,000 to more than $40 million in less than 4 years. Mr. Abdo will remain the Chief Executive Officer and Chairman of the Board.

Concurrently to the management restructuring, the Company has entered into a strategic alliance with Douglas Kiggins, founder of Mayo Energy Partners. Mr. Kiggins will assist Mr. Kacic in the development of the Company's Utah asset, with the target goal of drilling the first exploratory well in Utah by third Quarter 2011. Mr. Kiggins has participated in the drilling and development of over 250 oil and gas wells in Texas, Oklahoma and Colorado, with the deepest well reaching a total depth over 21,000 feet.

Everyone has been touched by America’s oil and natural gas industry. Farmers use fertilizer that comes from natural gas. Truckers use diesel fuel to transport goods to the markets.

Businesses count on oil and natural gas to make and sell their products and supply their services. If you purchase a loaf of bread, buy a new electronic gadget, or drive a car, you should consider yourself a part of the oil and natural gas industry. From airline pilots to welders, and all jobs in between, we’ve all take part in our energy future.

The industry reinforces jobs not just in exploring, producing, refining, transporting and marketing oil and natural gas, but also through the purchases it makes of other goods and services that support the industry’s operations. Equipment suppliers, construction companies, management specialists, and food service businesses are all a strong connection in the industry. These businesses turn around and purchase other goods.

Proper Power & Energy was formed in 2006 as an exploration and production company for oil and gas. The organization is committed to utilizing a very dynamic system of research and testing, and as a result of this extensive research and testing, have selected several sites with very good to excellent potential for productivity.

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Majestic Gold Corp. (TSX.V:MJS) (FSE:MJT) engages in the exploration and development of mineral properties in China. The company focuses on its gold project located in the prolific gold region of Song Jiagou in eastern Shandong Province. Majestic Gold Corp. is headquartered in Vancouver, Canada.

The Song Jiaguo Property is located on the Jiaodong Peninsula in Muping County, the Shandong Province, the People's Republic of China.

The property lies on the western edge of the Muping-Fushan Gold Belt, which hosts 20% of the known gold deposits on the Jiaodong Peninsula.

Gold production from the entire peninsula accounts for over 25% of China's annual gold production, presently estimated to be 288 tons or 9.3 M ounces.

Gold deposits in the belt are commonly controlled spatially by fault zones.

To the south of the property, the Pengjiakuang Gold Deposit (>650,000 oz) occurs in the same structural environment within Cretaceous Laiyiang conglomerates which underlie the Song Jiaguo Property.

Gold mineralization on Song Jiaguo is hosted by a series of steeply dipping, sub-parallel north-northeast trending fault zones within upper Cretaceous conglomerates overlying Proterozoic granitic rocks. The area of Song Jiaguo is interpreted as being the higher levels of a mesothermal system where gold bearing fluids have mineralized the matrix of the host conglomerates. The gold bearing quartz veins would then likely continue to much lower levels in the system.

For More Information On Majestic Gold: www.majesticgold.net

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AFC Enterprises Inc. (Nasdaq:AFCE) the franchisor and operator of Popeyes® restaurants, reported selected operating results for its fiscal 2010 fourth quarter and full year which ended December 26, 2010, and increased fiscal 2010 earnings guidance. Global same-store sales increased 6.0 percent in the fourth quarter compared to a 1.0 percent decrease last year. For the full year 2010, global same-store sales increased 2.6 percent compared to a 0.7 percent increase in 2009, exceeding the Company’s previous guidance of positive 2.0 percent to 2.5 percent. During the fourth quarter, the Popeyes system opened 22 domestic and 26 international restaurants, bringing full year 2010 openings to 106 restaurants, compared to 95 restaurants last year.

AFC Enterprises, Inc. engages in the development, operation, and franchising of quick-service restaurants under the Popeyes Chicken & Biscuits and Popeyes Louisiana Kitchen trade names.

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The KEYW Holding Corporation (Nasdaq:KEYW) announced that it plans to release its fourth quarter 2010 financial results in a press release after market close on February 7, 2011. A conference call has been scheduled to discuss these results on February 7 at 5:00 p.m. (EST). At that time, Management will review the Company's fourth quarter and FY2010 financial results, followed by a question-and-answer session to further discuss the results.

KEYW Corporation provides hardware and software development, and system integration services. It also offers test and evaluation, field support, computer and network operations, information security, and training services.

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Crown Equity Holdings Inc. (OTCPK:CRWE) anticipates receiving 1,000,000 shares of free trading shares from a third party (Mohamad Nehmeh) for two (2) weeks of advertisement services for Proper Power & Energy, Inc. (OTC:PPWE).

Crown Equity Holdings Inc. (OTCPK:CRWE) has received twenty-five thousand dollars in cash from Majestic Gold Corp. (TSX Venture Exchange (TSX.V:MJS) and the Frankfurt Stock Exchange (FSE:MJT)) for 30 (thirty) days of advertising, as well as for assistance in becoming a fully reporting publicly trading Bulletin Board company.