Ironwood Pharmaceuticals (NASDAQ:IRWD) announces that ZURAMPIC (lesinurad) is now available in pharmacies throughout the U.S. ZURAMPIC is approved as a once-daily oral tablet to be taken in combination with a xanthine oxidase inhibitor (XOI) for the treatment of hyperuricemia – high serum uric acid (sUA) levels in the blood – associated with gout in patients who have not achieved target sUA levels with an XOI alone.
In clinical trials, when added to allopurinol in patients with gout who failed to achieve target sUA levels with allopurinol alone, ZURAMPIC nearly doubled the number of patients who achieved sUA target of <6 mg/dL at month 6, reduced the mean sUA to <6 mg/dL by month 1 and maintained that level through month 12.
When added to febuxostat 80 mg in clinical trials, ZURAMPIC helped a greater, but not statistically significant, proportion of patients with tophaceous gout achieve sUA <5 mg/dL at month 6, and maintained that level through month 12. Acute renal failure has occurred with ZURAMPIC and was more common when ZURAMPIC was given alone. ZURAMPIC should be used in combination with an XOI.
ZURAMPIC (lesinurad) is a URAT1 inhibitor approved by the FDA for use in combination with a xanthine oxidase inhibitor (XOI) for the treatment of hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels (sUA) with an XOI alone.
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