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Ophthotech provides update on Zimura complement programs for treatment of eye diseases

Sep. 19, 2017 9:28 AM ETIVERIC bio, Inc. (ISEE) StockBy: SA News Team
  • Ophthotech Corporation (OPHT) initiates an open-label Phase 2a clinical trial of Zimura (avacincaptad pegol), the Company’s complement factor C5 inhibitor, in patients with wet age-related macular degeneration (AMD).
  • Zimura will be administered in combination with Lucentis (ranibizumab), an anti-vascular endothelial growth factor (anti-VEGF), in patients who have not been previously treated with anti-VEGF drugs. A range of Zimura dosing regimens will be assessed.
  • The Company will also initiate two additional clinical trials before year end. The first will assess Zimura monotherapy in Stargardt disease, a devastating orphan retinal disease-causing vision loss during childhood or adolescence.
  • The second will be an open-label Phase 2a clinical trial for idiopathic polypoidal choroidal vasculopathy, an age-related eye disease. Ophthotech is also planning a Phase 2a clinical trial of Zimura monotherapy for intermediate/posterior non-infectious uveitis, an orphan inflammatory disease of the back of the eye, for next year.
  • Ophthotech has decided to modify its ongoing Phase 2/3 clinical trial of Zimura monotherapy in geographic atrophy, a dry form of AMD, to accelerate the timeline for top-line data by reducing the number of patients.
  • Shares are up 1% premarket on light volume.

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