The fallout from Incyte's (INCY +0.7%) failed Phase 3 study of IDO inhibitor epacadostat in melanoma has spread to its collaboration partners.
Endpoints' John Carroll reports that enrollment will be terminated in Merck's (MRK -0.6%) study of the combination of Keytruda and epacadostat and Bristol-Myers Squibb (BMY -0.7%) will do the same in two combo trials with Opdivo.
AstraZeneca (AZN +0.6%) has backed away from its planned pivotal study of Imfinzi (durvalumab) + epacadostat in advanced lung cancer.
In mid-April NewLink Genetics (NLNK +0.4%) decided not to proceed with a Phase 1/2 study of lead candidate indoximod, also an IDO inhibitor.
Previously: Incyte's epacadostat flunks late-stage melanoma study (April 6)
Previously: NewLink down 8% after bailing on indoximod in melanoma study (April 16)
Subscribe for full text news in your inbox