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FibroGen's pamrevlumab shows treatment effect in mid-stage IPF study; shares up 2% after hours

May 21, 2018 4:34 PM ETFibroGen, Inc. (FGEN) StockBy: Douglas W. House, SA News Editor
  • FibroGen (NASDAQ:FGEN) is up 2% after hours on the heels of its announcement of positive results from a Phase 2b clinical trial, PRAISE, evaluating pamrevlumab in patients with idiopathic pulmonary fibrosis (IPF). The data were presented at the American Thoracic Society Conference in San Diego.
  • At week 24, the change from baseline in quantitative lung fibrosis (QLF) volume in the treatment group was 24.8 mL compared to 86.4 mL for placebo (p=0.0090) (the lower number indicates less fibrosis). At week 48, the QLF change from baseline was 75.4 mL in the pamrevlumab group versus 151.5 mL for placebo (p=0.038).
  • Phase 3-stage pamrevlumab is a fully human monoclonal antibody that binds to (inhibits) the activity of connective tissue growth factor (CTGF), a protein that plays a key role in the progression of fibrosis (scarring) and related diseases.

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