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Aduro Bio announces launch of early-stage study of ADU-214 in lung cancer

Jun. 07, 2018 4:20 PM ETAduro Biotech, Inc. (ADRO) StockBy: Douglas W. House, SA News Editor
  • Aduro Biotech (NASDAQ:ADRO) announces that licensee Janssen Biotech (JNJ) has initiated a Phase 1b clinical trial assessing ADU-214, combined with Bristol-Myers Squibb's (BMY) Opdivo (nivolumab), in patients with advanced/metastatic non-small cell lung cancer, specifically, mesothelin-positive relapsed/refractory Stage IIIB or Stage IV adenocarcinoma of the lung.
  • The primary endpoint of  the 170-subject study is objective response rate (ORR) at every eight-week time point during year 1 and every 12 weeks thereafter. According to ClinicalTrials.gov, the estimated primary completion date is October 2020.
  • ADU-214 is based on Aduro's LADD technology platform. LADD (live-attenuated double-deleted) Listeria monocytogenes are strains of bacteria that are engineered to induce a potent innate immune response and to express tumor-associated antigens to induce tumor-specific T-cell-mediated immunity.
  • Shares are up 1% after hours.
  • Previously: Aduro bags $22.4M in LADD-related milestones from Janssen Biotech (Feb. 1, 2016)

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