Macrogenics down 14% premarket on doubts with margetuximab data

Oct. 23, 2019 8:38 AM ETMacroGenics, Inc. (MGNX)MGNXBy: Douglas W. House, SA News Editor
  • Macrogenics (NASDAQ:MGNX) slips 14% premarket, albeit on only 620 shares, on the heels of updated survival data from a Phase 3 clinical trial evaluating margetuximab in patients with HER2-positive breast cancer.
  • The combination of the HER2-targeting monoclonal antibody and chemo showed a median increase in overall survival (OS) of 1.8 months (21.6 months vs. 19.8 months) compared to the combination of Roche's Herceptin + chemo with 11.5% less risk of death (hazard ratio = 0.885). The confidence interval for the hazard ratio, however, was 0.693 - 1.130 with a p value of 0.326, meaning, basically, that treatment with margetuximab may not have improved survival at all.

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