Moderna leads with antibody response in COVID-19 booster trial in U.K.
Dec. 03, 2021 6:49 AM ETModerna, Inc. (MRNA), AZN, PFE, BNTXVALNBy: Dulan Lokuwithana, SA News Editor49 Comments
- According to a peer-reviewed study published in The Lancet on Thursday, Moderna (NASDAQ:MRNA) COVID-19 vaccine has shown the strongest antibody effect in a trial that evaluated the different combinations of COVID-19 vaccines as boosters.
- The Phase 2 "COV-Boost" study conducted across 18 different U.K. locations involved nearly 2,900 individuals aged over 30 years. Half in the study had received two doses of Oxford-AstraZeneca (NASDAQ:AZN) vaccine, and the rest had received the Pfizer (NYSE:PFE)/BioNTech (NASDAQ:BNTX) vaccine.
- The trial was designed to evaluate the safety and efficacy of seven booster vaccines developed by AstraZeneca (AZN), Pfizer (PFE)/ BioNTech (BNTX), Novavax (NASDAQ:NVAX), Johnson & Johnson (NYSE:JNJ), Moderna (MRNA), Valneva (NASDAQ:VALN) and CureVac (NASDAQ:CVAC).
- While all seven vaccines except Valneva’s (VALN) boosted immunity in those who had received initial doses of Pfizer (PFE)/ BioNTech (BNTX), all seven had upped the immunity level when given 10 – 12 weeks after the initial regimen of the AstraZeneca (AZN) vaccine.
- Notably, Moderna (MRNA) COVID-19 shot had generated the strongest booster effect leading to an over 32-fold rise in antibody level in the AstraZeneca (AZN) group and over 11-fold increase in the Pfizer (PFE)/ BioNTech (BNTX) group, The Guardian reported.
- Read: Shortly after the FDA authorized its COVID-19 vaccine as an additional dose in the U.S., Piper Sandler expected Moderna (MRNA) to take market share from Pfizer (PFE)/ BioNTech (BNTX) in the U.S. market for booster shots.