Karyopharm begins dosing in late-stage study of selinexor combo therapy for multiple myeloma

May 25, 2022 8:35 AM ETKaryopharm Therapeutics Inc. (KPTI)BMYBy: Ravikash, SA News Editor

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  • Karyopharm Therapeutics (NASDAQ:KPTI) and the European Myeloma Network (EMN), a collaboration of centers for multiple myeloma in Europe and Australia, said the first patient was dosed in the collaborative EMN29/XPORT-MM-031 study.
  • The global phase 3 trial is evaluating an all-oral regimen of Karyopharm's selinexor, sold as Xpovio, in combination with Bristol-Myers Squibb's (BMY) chemo drug Pomalyst (pomalidomide) and low-dose dexamethasone (SPd) versus BMY's Empliciti (elotuzumab), pomalidomide, and dexamethasone (EPd) in patients with relapsed or refractory multiple myeloma (MM).
  • The patients will have received one to four prior lines of therapy, before being enrolled in the study.
  • The company said the study follows encouraging data from an all-oral arm of a phase 1b/2 trial, dubbed STOMP, and a phase 2 study called XPORT-MM-028 in which selinexor was evaluated in combination with Pomalyst and low-dose dexamethasone in patients with relapsed or refractory MM who received at least two prior lines of therapy.
  • MM is a cancer that forms in a plasma cell, a type of white blood cell.

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