AstraZeneca Enhertu data could expand use in breast cancer

Jun. 05, 2022 11:46 AM ETAZNBy: Jonathan Block, SA News Editor7 Comments

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  • New data on AstraZeneca's (AZN) Enhertu (trastuzumab) could position the oncologic for expanded use in breast cancer.
  • Results from the phase 3 DESTINY-Breast04 study released Sunday showed that patients treated with Enhertu saw a 49% reduction in the risk of disease progression or death versus other chemotherapy in patients with HER2-low metastatic breast cancer with HR-positive disease.
  • Also, median progression-free survival of 10.1 months was observed in the Enhertu group compared to 5.4 months with chemotherapy.
  • Median overall survival of 23.9 months was seen with Enhertu versus 17.5 months with chemotherapy.
  • DESTINY-Breast04 was conducted in patients whose tumors express low levels of the protein HER2. This group accounts for more than half of all breast cancer patients.

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