TCR2 Therapeutics stock rises 16% as cell therapy for solid tumors shows promise in trial

Sep. 28, 2022 8:04 AM ETTCR2 Therapeutics Inc. (TCRR)By: Ravikash, SA News Editor1 Comment

Medical Science Laboratory with Diverse Multi-Ethnic Team of Microbiology Scientists Have Meeting on Developing Drugs, Medicine, Doing Biotechnology Research. Working on Computers, Analyzing Samples


TCR2 Therapeutics (NASDAQ:TCRR) said its cell therapy gavo-cel showed clinical benefit in patients with mesothelin-expressing solid tumors in a phase 1 portion of a phase 1/2 trial.

As of Sept. 9, 32 patients (including 23 mesothelioma, eight ovarian cancer and one cholangiocarcinoma) had received a single gavo-cel infusion in the phase 1 portion. The patients were heavily pretreated with a median of five prior lines of therapy.

Gavo-cel showed a disease control rate (DCR - defined as response /sustained stable disease for at least three months) of 77%. Meanwhile, 28 of the 30 patients evaluable for efficacy saw tumor regression of their target lesions, ranging from 4% to 80%, the company said in a Sept. 28 press release.

TCR2 added that Eight patients saw target lesion regression >30%, six of whom (four with mesothelioma and two with ovarian cancer) achieved a partial response (PR) according to RECIST 1.1 criteria, including one patient who also achieved a complete metabolic response. One patient with cholangiocarcinoma was also considered to have achieved a PR.

"These are remarkable data in the context of solid tumors where there have been significant challenges with current CAR-T therapies. I am particularly excited by this second RECIST response in ovarian cancer as it supports the meaningful clinical activity of gavo-cel in a large patient population," said TCR2 President and and CEO Garry Menzel.

TCR2 noted that the median overall survival (OS) for patients with malignant pleural/peritoneal mesothelioma (MPM) was 11.2 months, while median progression-free survival (PFS - length of time during/after therapy a patient lives with the disease without it getting worse) for patients with MPM was 5.6 months.

The overall response rate (ORR) among patients who received gavo-cel following lymphodepletion chemotherapy was 22% by blinded independent central review (BICR) and 26% by investigator assessment. By BICR, the ORR was 21% among patients with MPM and 29% among those with ovarian cancer, according to the company.

TCR2 noted that after dose-limiting toxicity (DLT) at dose level (DL) 5 was seen in September 2021 the study proceeded to a dose de-escalation portion.

The company said two DLTs were seen: one case of Grade 3 pneumonitis at DL1 that resolved with anti-cytokine therapy, and one case of Grade 5 bronchioalveolar hemorrhage at DL5.

All three patients treated at DL5 experienced severe cytokine release syndrome (CRS), which led to the safety review team recommending de-escalation, according to the company.

The most frequent Grade 3 or higher non-blood toxicity among patients treated at the RP2D was CRS, which was reported in 15% of patients, TCR2 noted.

Gavo-cel was generally well tolerated with a manageable adverse event profile up to DL 5, as per the company.

TCRR +15.98% to $1.96 premarket Sept. 28

Recommended For You

Comments (1)

To ensure this doesn’t happen in the future, please enable Javascript and cookies in your browser.
Is this happening to you frequently? Please report it on our feedback forum.
If you have an ad-blocker enabled you may be blocked from proceeding. Please disable your ad-blocker and refresh.