Vertex Therapeutics: The Pain Comes With The Territory For Suzetrigine

Summary

• I last wrote here several months ago about the sodium channel (NaV1.8) inhibitor VX-548 (now known as suzetrigine), which is under investigation as a pain relief medication.
• In that earlier post on this drug, it had shown some very interesting (though modest) activity in post-surgical patients, albeit with some questions about its efficacy relative to Vicodin standard-of-care.
• Vertex has been running a number of trials because if there’s one thing that we can take away from the failed drug development projects of the past, it’s that there are many kinds of pain.
• Just before the holiday break, Vertex reported on another of these trials with suzetrigine in sciatica patients.

Totojang

I last wrote here several months ago about the sodium channel (NaV1.8) inhibitor VX-548 (now known as suzetrigine), which is under investigation as a pain relief medication. There is of course a gigantic need for effective but nonaddictive