Arcellx: Anito-Cel With D-Domain Differentiation Looks To Capture R/R MM Market

Jul. 15, 2025 4:51 PM ETArcellx, Inc. (ACLX) StockGILD, GILD:CA, ACLX
Terry Chrisomalis
Investing Group Leader

Summary

  • Arcellx, Inc. is advancing its lead CAR-T therapy, anito-cel, for relapsed/refractory multiple myeloma, with the pivotal phase 3 iMMagine-3 trial underway.
  • Recent positive phase 2 iMMagine-1 data support the potential of anito-cel, especially in 2nd-line+ multiple myeloma patients who failed prior therapies.
  • The FDA has allowed a dual primary endpoint—progression-free survival and MRD-negativity—in the ongoing phase 3 iMMagine-3 study, enhancing regulatory prospects.
  • With a strong partnership with Kite Pharma, ACLX aims to potentially launch anito-cel for 2nd-line+ multiple myeloma patients by 2026.
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Arcellx, Inc. (NASDAQ:ACLX) is making significant progress in the development of its lead CAR-T cell therapy, anitocabtagene Autoleucel (anito-cel), for the treatment of patients with relapsed/refractory multiple myeloma (r/r MM). It is currently in the process of evaluating

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This article was written by

Terry Chrisomalis
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Terry Chrisomalis is a private investor in the Biotech sector with years of experience utilizing his Applied Science background to generate long term value from Healthcare.

He is the author of the investing group Biotech Analysis Central which contains a library of 600+ Biotech investing articles, a model portfolio of 10+ small and mid-cap stocks with deep analysis for each, live chat, and a range of analysis and news reports to help Healthcare investors make informed decisions.

Analyst’s Disclosure:I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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